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Recombinant Pig Tumor necrosis factor receptor superfamily member 6 (FAS)

Recombinant Pig Tumor necrosis factor receptor superfamily member 6 (FAS)

Code: CSB-CF008433PI

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Size:

20μg100μg

US$4859

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Express system: in vitro E.coli expression system

Species: Sus scrofa (Pig)

Tag Info: N-terminal 10xHis-tagged

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Target Background

Product Details

Target Names

FAS

Uniprot NO.

O77736

Species

Sus scrofa (Pig)

Source

in vitro E.coli expression system

Expression Region

17-332

Target Protein Sequence

GPLSKGDDAQVTDPDSEMVKLNITKRESECPEGQHREGQFCCQPCPPGKRKHADCTSPGGAPQCVPCSEGEDYTDKNHHSSKCRRCRVCDGEHGLEVEKNCTRTQNTKCRCKPNFFCHTSQCEHCNPCTTCEHGVIENCTPTSNTKCREVFQSAGSRSNLHWLWALLILIPVPALVYREVKRRCRRKENGYQKPITSNAEEVPMIKDVDLGKYITRIAEQMKITEVKDFVRKNGIEETKIDEIMHDNPKDTAEQKVQLLRNWYLYHGKKDAYCTLIQGLRKAKLSALADKINDIVQKDVTSEQENANSQNENESLT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

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Target Background

Function(From Uniprot)

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

Gene References into Functions

Fas was expressed on fetal pig pancreatic cells, both beta and non-beta cells, and the level of expression could be upregulated by exposure to interleukin 1beta PMID:15303979
The expression of FAS and FAS ligand in splenic macrophages co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus is reported PMID:17321702

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Membrane raft.

Database Links

UNIGENE: Ssc.14497

KEGG: ssc:396826

STRING: 9823.ENSSSCP00000011136

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