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Recombinant Pig Somatostatin receptor type 2 (SSTR2)

Recombinant Pig Somatostatin receptor type 2 (SSTR2)

CSB-CF022725PI

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20μg100μg

US$5256

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Express system: in vitro E.coli expression system

Species: Sus scrofa (Pig)

Tag Info: N-terminal 10xHis-tagged

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Target Background

Product Details

Target Names

SSTR2

Uniprot NO.

P34994

Species

Sus scrofa (Pig)

Source

in vitro E.coli expression system

Expression Region

1-369

Target Protein Sequence

MDMAYELLNGSQPWLSSPFDLNGSVATANSSNQTEPYYDLTSNAVLTFIYFVVCIIGLCG NTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMT VDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIY AGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGI RVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVVL TYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTL LNGDLQTSI

Protein Length

Full length protein

Tag Info

N-terminal 10xHis-tagged

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Description

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Target Background

Function

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Gene References into Functions

SRIF can inhibit testosterone secretion through the sst2A receptor; local inhibitory action of SRIF is probably autocrine & might involve testosterone-induced increase of sst2 receptor expression in immature Leydig cells [SST2A] PMID:12646058
is a potent inhibitory receptor displaying a unique set of interrelated dynamic features of agonist-dependent dimerization, dissociation, internalization, and reassociation, a cascade of events that might be critical for receptor function PMID:17053026
Data demonstrate that urotensin II and urotensin II-related peptide directly activate somatostatin receptors 2 and 5 and thus mimic the effect of somatostatin on its cognate receptors. PMID:18289730

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cytoplasm.

Protein Families

G-protein coupled receptor 1 family

Database Links

UNIGENE: Ssc.42757

KEGG: ssc:497059

STRING: 9823.ENSSSCP00000018276

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