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Recombinant Pig Glutamate carboxypeptidase 2 (FOLH1)

Recombinant Pig Glutamate carboxypeptidase 2 (FOLH1)

CSB-CF008782PI

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20μg100μg

US$8114

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Express system: in vitro E.coli expression system

Species: Sus scrofa (Pig)

Tag Info: N-terminal 10xHis-tagged

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Target Background

Product Details

Target Names

FOLH1

Uniprot NO.

O77564

Species

Sus scrofa (Pig)

Source

in vitro E.coli expression system

Expression Region

1-751

Target Protein Sequence

MWNPLHETDSTSVAWRRPRWLCAGALVLAAGLFVLGFLFGWFIKSPNEAANISPQHNVKKAFLDELKAENIKTFLYNFTRIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYPNKTRPNYISIIDEDGNEIFNTSLFEPPPPGYENVSDVVPPFSAFSPQGMPEGDLVYVNYARTEDFFKLERDMKINCSGKILIARYGKIFRGNKVKNAQLAGAKGIILYSDPADYFAPGVQSYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRLQIAEAVGLPRIPVHPIGYSDAQKLLEKMGGSAPPDDSWKGSLHVPYNVGPGFTGNFSTQKVKMHIHSDNKVKRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGKLKKEGWRPRRTVLFASWDAEEYGLFGSTEWAEENSRILQERGVAYINADSSIEGNYTLRVDCTPLMYSLVYNLTKELQSPDEGFEGKSLFESWNEKSPSPEFSGLPRISKLGSGNDFEVFFQRLGIASGRARYTKDWVTNKFSSYPLYHSVYETYELVEKFYDPTFKYHLAVAQVRGGIVFELANSVVRPFDCRDYAVVLRNYADKLYNISMNHPQEMKAYSVSFDSLFSAVKNFTEIASNFSERVQDLDKNNPILLRIMNDQLMFLERAFIVPLGLPDRAFYRHVIYAPSSHNKYMGESFPGIYDALFDIENKVDPSKAWGEVKRQISIAAFTVQAAAGTLREVA

Protein Length

full length protein

Tag Info

N-terminal 10xHis-tagged

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Description

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Target Background

Function

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate.; Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

Gene References into Functions

Tissues such as prostate and testes exhibit different GCPII expression levels among the species studied (human, rats, swine). PMID:18076021
intestinal GCPII and intestinal and hepatic RFC all exhibit ontogenic changes in the pig that are reflected in postnatal folate status PMID:19033540

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Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Protein Families

Peptidase M28 family, M28B subfamily

Tissue Specificity

High expression in the duodenum and in the jejunum brush-border membrane. Weak expression in kidney.

Database Links

UNIGENE: Ssc.14488

KEGG: ssc:397677

STRING: 9823.ENSSSCP00000027466

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