Recombinant Mouse Vesicle-associated membrane protein 8 (Vamp8)

1. in addition to a secretory role, VAMP8-mediates trafficking of NOX2 to endosomes and phagosomes and this promotes induction of cytolytic T cell immune responses PMID:28688576
2. This report highlights the importance of the VAMP8 secretory machinery in facilitating mucus release from intestinal goblet cells and the dire consequences that occur during disease pathogenesis if these pathways are not functional. PMID:28974617
3. acute inhibition of VAMP8-mediated secretion during pancreatitis triggers intracellular trypsin accumulation and loss of the early endosomal compartment PMID:28242757
4. These findings reveal a role for VAMP8 in LC3-associated phagocytosis and highlight a novel mechanism exploited by L. major promastigotes to interfere with the host antimicrobial machinery PMID:27280768
5. VAMP8-mediated secretion is dependent on anterograde endosomal trafficking. PMID:25138214
6. Leishmania evades host immunity by GP63-mediated VAMP8 cleavage. PMID:23870310
7. VAMP8 mediates insulin granule recruitment to the plasma membrane, which partly accounts for GLP-1 potentiation of glucose-stimulated insulin secretion. PMID:22841572
8. VAMP8 knockout mice were used to show that the SNARE machinery plays a critical role in the process of granule homotypic fusion. PMID:22450911
9. VAMP8 regulates mucin granule exocytosis in airway goblet cells, and reduction of its expression may provide a novel therapeutic target to ameliorate airway mucus obstruction in lung diseases PMID:22144578
10. that granule-to-granule fusion is regulated by VAMP8 containing SNARE complexes distinct from those that regulate primary granule fusion. PMID:21733851
11. data demonstrate that, in the absence of VAMP8, the relative subcellular distribution of GLUT4 is altered, resulting in increased sarcolemma levels that can account for increased glucose clearance and insulin sensitivity PMID:20876717
12. VAMP8 mediates the regulated fusion of AQP2-positive vesicles with the plasma membrane. PMID:19841070
13. VAMP8 has a role in regulated exocytosis of pancreatic acinar cells by serving as a v-SNARE of zymogen granules PMID:15363411
14. VAMP-8 is required for release from dense core granules, alpha granules, and lysosomes. PMID:17065550
15. These results suggest that VAMP8 may act as a v-SNARE for regulated secretion of the entire exocrine system. PMID:17215514
16. VAMP-8 segregates secretory lysosomal granule exocytosis in mast cells from cytokine/chemokine molecular trafficking pathways. PMID:18203950
17. Functionally inhibits phagocytosis in dendritic cells upon exposure to bacteria PMID:18292538
18. VAMP8 is the zymogen granule-SNARE that mediates basolateral exocytosis in alcoholic pancreatitis. In addition, VAMP8 is critical for zymogen granule-zymogen granule homotypic fusion. PMID:18535671
19. VAMP8 has a specific function in the thymic stroma affecting the proliferation and apoptosis of T lymphocytes during maturation in the thymus. PMID:18923845
20. these results highlight the role of caspases in regulating VAMP-8 expression and subsequently phagocytosis during maturation of dendritic cells. PMID:19607812
21. Results clearly show that VAMP8 is one of the v-SNARE that regulate the lytic ability of CTL by influencing the ability of the lytic granules to fuse with the plasma membrane and release its contents. PMID:19830729

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UNIGENE: Mm.1838

KEGG: mmu:22320

STRING: 10090.ENSMUSP00000059501