Recombinant Mouse Tumor necrosis factor receptor superfamily member 1B (Tnfrsf1b)

1. MPTP induced TNF-alpha signaling through TNFR2 mediated pathway and recruited p65-p52 dimer in hippocampal nucleus which is reported to have protective effect on hippocampal neurons indicated by unchanged neuronal count in hippocampus in treated groups with respect to control. PMID:29481885
2. study reports an important role for TNFR2 on low-affinity-primed secondary effector CD8+ T cells; results demonstrate the importance of TNF signaling in low-affinity, cross-reactive CD8+ T cell responses during heterologous immunity PMID:27481849
3. our findings implicate TNFR2 in supporting myeloid-derived suppressor cells -mediated immune suppression and metastasis in the liver PMID:26483205
4. TNFR2 blockade appears to disrupt commensal bacteria-host immune symbiosis to reveal autoimmune demyelination in genetically susceptible mice. PMID:26475926
5. TNFR2 protects mice from colitis by inhibiting the expansion of colonic CD8(+) T cells. PMID:26072395
6. To determine the role of TNF-TNFR2/p75 signaling in ischemia-induced inflammation and muscle regeneration, we subjected wild-type and TNFR2/p75 knockouts to hind limb ischemia. PMID:25466901
7. Results demonstrate novel roles of TNFRII in the regulation of Abeta production, suggesting a potential therapeutic strategy for Alzheimer's disease by up-regulating TNFRII levels and elevating phosphorylated IkappaBalpha by SUMOylation. PMID:24824215
8. PGRN protection of endoplasmic reticulum stress induced apoptosis was abolished when TNFR2 signaling was blocked. PMID:24703938
9. TNFR2 signaling by itself is both sufficient and required to induce Vbeta5+ Treg expansion. PMID:25098294
10. TNF-alpha produced by alveolar macrophages induces Th2 cell response, via TNFR2 on Natural killer T cells. PMID:24191851
11. both young and aged mice deficient of TNFR2 performed poorly in the contextual fear conditioning test and displayed decreased anxiety-like behavior PMID:24135018
12. Mice lacking TNFRp75 exhibit greater control of M. tuberculosis infection compared with WT mice. TNFRp75-/- mice developed effective bactericidal granulomas and demonstrated increased pulmonary recruitment of activated dendritic cells. PMID:24569452
13. TNFR2 deficiency significantly impaired transmembrane TNF-alpha-induced release of IL-10 and NO and inhibition of T cell proliferation by MDSC supernatant. TNF-alpha acts as a potent activator of MDSCs via TNFR2 and promotes tumor immune escape. PMID:24379122
14. Our results indicate that TNFR2 signaling is required for the innate airway hyperresponsiveness that develops in obese mice, and suggest that TNFR2 may act by promoting IL-17A, endothelin, and/or trkB expression. PMID:22584291
15. In immune-mediated inflammatory bowel disease models, TNFR2 signaling increases long MLCK expression, resulting in tight junction dysregulation, barrier loss, and induction of colitis. PMID:23619146
16. High Soluble TNFR2 is associated with infarct size and ventricular dysfunction in ST-elevation myocardial infarction PMID:23405158
17. We propose a novel mechanism in which TNF activates TNFR2 on Treg cells and thereby expands this immunosuppressive immune cell population. PMID:23385062
18. In a chronic model of proliferative nephritis, IRF1 and renal-expressed TNFR2 were essential for sustained macrophage accumulation. PMID:23623383
19. Lipopolysaccharide-induced pulmonary alveolar inflammation upregulates alveolar macrophage-mediated production of sTNFR p75. Mechanical ventilator-induced lung injury enhances alveolar epithelial permeability leading to increased sTNFRp75. PMID:21512145
20. results suggest that TNFR2 expressed on podocytes and its canonical NF-kappaB signaling may directly interpose the compound pathogenic responses by podocytes to TNF-alpha, in the absence of other TNFR2-positive renal cell types in proliferative podocytopathies PMID:21221075
21. p75 is essential for tumor angiogenesis and survival in highly vascularized murine lung tumor xenografts. PMID:22158049
22. Both internalization and ASK1-interacting protein-1 association are required for TNFR2-dependent JNK and apoptotic signaling in endothelial cells. PMID:22743059
23. this suggests that the protective effect seen in mice lacking TNFR2 results rather from environment-induced attenuation by low dose bacterial endotoxins than from missing pro-inflammatory signalling via the TNFR2. PMID:22449555
24. TNF-alpha signaling through TNFR2 is essentially involved in the bile acid synthesis and excretion of lipids, resulting in its beneficial effects. PMID:21850461
25. co-activation of TNFR2 during beta-AR stress is anti-inflammatory and counterbalances pro-inflammatory, pro-hypertrophic effects of unopposed TNFR1 activation PMID:21691899
26. expression on non-haematopoietic cells is required for Foxp3+ Treg-cell function and disease suppression in EAE PMID:22105853
27. TNFR1, not TNFR2, mediates TNF-alpha stimulation of dendritic cell maturation and CD8 T cell response to recombinant mouse hepatitis virus infection in vivo. PMID:21709152
28. requirement for TNFR2-expression on murine natural Tregs (nTregs) and induced Tregs (iTregs) in mediating suppression of colitis PMID:21572024
29. These results provide the first in vivo evidence for the origin and regulation of soluble TNFR2 in serum. PMID:21258364
30. TR2 is an important mediator in colitis, and may serve as a therapeutic target in inflammatory bowel disease. PMID:21347711
31. Tumor necrosis factor-alpha signaling via TNFR1/p55 is deleterious whereas TNFR2/p75 signaling is protective in adult infarct myocardium PMID:21153348
32. Mesenchymal stem cell TNFR2 plays an important role in MSC-mediated cardiac protection after myocardial ischemia. PMID:20160664
33. critical for developing macrophages that control of T-cell proliferation PMID:20518824
34. These data indicate that, through TNFR2, microglia may contribute to the counter-regulatory response activated in neuropathological conditions. PMID:20600925
35. These data suggest a protective role for TNFR2/Fas in the pathogenesis of traumatic brain injury. PMID:20205514
36. Intratumoral Tregs expressing more TNFR2 are able to overcome the greater resistance to suppression of intratumoral conventional T cells, resulting in a dominant immunosuppressive tumor environment. PMID:20525892
37. Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signaling. PMID:20139367
38. TNFR2(KO) myocardium showed little Etk activation and cell cycle entry but increased ASK1 activation and apoptosis. PMID:19788501
39. TNF type 2 receptor (p75) lowers the threshold of T cell activation PMID:11739497
40. Interaction of TNFR2 with TNF is important in the pathogenesis of wasting associated with acute graft-versus-host-disease (GVHD)and in the generation of histopathological lesions of intestinal GVHD. PMID:11884480
41. CD120b signaling is required for optimal CD40-induced IgM secretion by B cells. PMID:11907088
42. Review. Blockade of the p75TNFR may be helpful in treating systemic autoimmunity since its function may be essential for systemic tissue damage. PMID:12220546
43. Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria. PMID:12228317
44. p75 TNF-alpha receptor 2 is required for the regulation of airway hyperresponsiveness (AHR) by gamma delta T cells, since p75-deficient mice develop AHR to a similar degree as control mice following sensitization and challenge with allergen. PMID:12370348
45. TNFRs within the CNS play a significant role in shaping the outcome of TNF signaling during neuroimmune interactions. PMID:12522266
46. Role differs fom that of p55TNFR in the induction of PAI-1. PMID:12598326
47. LPS triggers a rapid shedding of CD120b via a protein kinase C- and Src-independent pathway mediated by p38 MAPK, furin, and metalloproteinase. PMID:12663667
48. TNF/TNFR2 interactions facilitate generation of FasL-dependent CTL effector pathways that play an important role in in vivo antiviral-immune responses in the liver. PMID:12960267
49. Skin tumour multiplicity was significantly reduced in TNFR1-/- and TNFR2-/- mice compared to wild-type mice. PMID:14661063
50. Impaired induction of major histocompatibility complex class I glycoproteins in TNF-R2-deficient mice following axotomy of facial motor nucleus underscores the central role of TNF in the immune activation of the injured nervous system. PMID:14961564

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UNIGENE: Mm.235328

KEGG: mmu:21938

STRING: 10090.ENSMUSP00000030336