Recombinant Mouse Thromboxane A2 receptor (Tbxa2r)

1. The results suggest that EP3 along with TP contributes to vasoconstrictor responses evoked by PGI2, and hence imply a novel mechanism for endothelial cyclooxygenase metabolites (which consist mainly of PGI2) in regulating vascular functions. PMID:28165064
2. platelet GP6 and thromboxane A2 receptor have a role in promoting inflammatory macrophage phenotype in skin inflammation PMID:27818280
3. Genetic deletion of thromboxane receptor in adipose-derived stromal cells accelerated endothelial cell differentiation. PMID:26957525
4. PKCalpha deficiency leads to pulmonary vascular hyperresponsiveness to TXA2, possibly via increased pulmonary arterial TP receptor expression. PMID:26890419
5. Uridine adenosine tetraphosphate induced aortic contraction depends on activation of TX synthase and thromboxane A2 receptor, which partially requires the activation of P2X1R through an endothelium-dependent mechanism. PMID:25921923
6. It is an active player in the pathogenesis of Alzheimer's disease. PMID:25457549
7. Adhesion of platelets through thromboxane A receptor signaling facilitates liver repair during acute chemical-induced hepatotoxicity. PMID:25921763
8. The results indicate that the beta1-subunit can form a tripartite complex with TP and MaxiKalpha, has the ability to associate with each protein independently. PMID:23255603
9. Blocking the expression of the thromboxane receptor significantly suppresses the prothrombotic effect of C-reactive protein. PMID:22879580
10. The thromboxane A(2) receptor agonist 11-deoxy PGF(2alpha) can partially alleviate embryo crowding in the Lpar3((-/-)) females and embryo crowding likely contributes to reduced litter size in the Lpar3((-/-)) females. PMID:22222195
11. We show here that thromboxane receptor in the striatum locally facilitates dopamine overflow. PMID:21749493
12. thromboxane A2 receptor signalling does not contribute critically to the pathogenesis of ischemic acute kidney injury PMID:21449636
13. Thromboxane A2 receptor activation via PKC-zeta-mediated NAD(P)H oxidase activation increases superoxide and peroxynitrite, resulting in eNOS uncoupling in endothelial cells. PMID:20947827
14. Genetic variations exist in this protein in platelet function disorders. PMID:20162250
15. thromboxane synthase, prostacyclin synthase and thromboxane receptor have roles in atherosclerotic lesions and correlate with plaque composition PMID:19735918
16. TXA2-TP signaling modulates acquired immunity by negatively regulating DC-T cell interactions. PMID:12778172
17. Thromboxane A2 (TXA2)-mediated platelet secretion and aggregation are important in thrombosis and the stable TXA2 analogue, U46619, induces two waves of platelet secretion, each of which precedes a distinct wave of platelet aggregation PMID:12796499
18. Activation of TP receptors promotes T cell proliferation, and contributes to immune-mediated tissue injury. PMID:14662837
19. Thromboxane A2 receptor has a role in the pathogenesis of angiotensin II-dependent hypertension. PMID:14718360
20. TP -/- mice have a basal increase in renal vascular resistance and filtration fraction associated with reactive oxygen species. PMID:15213069
21. TXA2 promotes and PGI2 prevents the initiation and progression of atherogenesis through control of platelet activation and leukocyte-endothelial cell interaction in Apolipoprotein e deficient mice. PMID:15372102
22. Baseline systolic blood pressure did not differ between TP(-/-) and TP(+/+) mice. PMID:15635218
23. Endothelial cells genetically lacking thromboxand receptor show reduced inflammatory responses when stimulated with isoprostane F2alpha-III but not other oxidized lipids. PMID:16267259
24. Endogenous activation of TXA2 receptor by eicosanoids did not modulate spontaneous neovascularization in the setting of ischemia. PMID:16385086
25. Increased responsiveness of thromboxane A(2) receptors occurs in diabetic ApoE-KO mouse kidneys. PMID:17942572
26. blockage of thromboxane receptors provoked embolus formation in wildtype blood PMID:18000613
27. 12/15LO- and TxA(2) receptor-mediated pro-atherogenic effects are two distinct pathways PMID:18206890
28. COX-1 contributes to the enhanced formation of both PGI(2) and TXA(2) in atherosclerosis, and to the development of the disease PMID:18514659
29. in L-NAME hypertension, TP receptors contribute to elevated blood pressure and cardiac hypertrophy; In this model, TP receptors also provided unexpected protection against kidney injury. PMID:18684890
30. Demonstrate that isoprostanes inhibit angiogenesis via activation of the TBXA2R. PMID:18802021
31. thromboxane receptor knockout mice showed normal pain behavior in all tests PMID:18938093
32. the results from the present and previous studies suggest an autocrine loop, involving cyclooxygenase-2, thromboxane A synthase, and thromboxane A2 and its receptor, in cyclooxygenase-2-dependent inhibition of StAR gene expression. PMID:19325001
33. Thromboxane A2 receptor stimulation impairs insulin signaling in vascular endothelial cells by selectively activating the Rho/Rho-associated kinase/LKB1/PTEN pathway. PMID:19403525

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UNIGENE: Mm.4545

KEGG: mmu:21390

STRING: 10090.ENSMUSP00000100962