Recombinant Mouse Thrombomodulin (Thbd)

1. macrophage infiltration and neointima formation following arterial ligation-induced vascular injury were higher in wild-type than in myeloid-specific thrombomodulin-deficient mice PMID:27808085
2. discovery of a novel physiological function of thrombomodulin-dependent activated protein C generation within the CNS PMID:27590316
3. The present study found that the fifth epidermal growth factor-like domain of thrombomodulin (TME5) possesses the cytoprotective function in association with an increase in levels of anti-apoptotic myeloid cell leukemia-1 protein in an activated protein C-independent PMID:27427915
4. the lectin-like domain of thrombomodulin is critically involved in host defence against E. coli induced acute pyelonephritis PMID:26573396
5. Identified Nur77/Nor1 as novel regulators of thrombomodulin expression and function in vascular endothelial cells. PMID:26634653
6. TM expression in corneal epithelium was modulated during the corneal wound healing process, and may be regulated by PDGF-BB. In addition, rTMD23 has therapeutic potential in corneal injury PMID:25816372
7. Membrane-bound TM in macrophages plays an essential role in the development of abdominal aortic aneurysms by enhancing proinflammatory mediator elaboration, macrophage recruitment, and oxidative stress. PMID:26338301
8. Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice PMID:25860286
9. the recombinant epidermal growth factor-like domain plus serine/threonine-rich domain of thrombomodulin suppresses the inflammatory response in mice PMID:25609841
10. Thrombomodulin may modulate allergic responses by inhibiting the activation of both eosinophils and mast cells. PMID:25497974
11. Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 and an independent mechanism. PMID:24368584
12. The lectin-like domain of TM does not play an important role in the host response to M. tuberculosis infection in mice. PMID:24136651
13. Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism. PMID:24098750
14. TM has a critical role in skin differentiation and wound healing. PMID:23321922
15. TM's lectin-like domain constrains glucose-induced complement activation on endothelial cells and podocytes and ameliorates albuminuria and glomerular damage. PMID:23014597
16. FFAs inhibit TM-EPCR-Protein C system in endothelial cells through activating JNK signaling, which may be a mechanism for the prothrombotic state in metabolic syndrome. PMID:22903729
17. Genetic or acquired thrombomodulin defects might have an impact on the severity of microangiopathic lesions after exposure to Shiga toxin-producing E. coli infections. PMID:22942429
18. we conclude that monocytic membrane-bound thrombomodulin participates in the LPS- and gram-negative bacteria-induced inflammatory response. PMID:22573811
19. Recombinant thrombomodulin domains 2 and 3 protein significantly reduces atherosclerosis and neointima formation through its thrombin-binding ability. PMID:21840881
20. RHBDL2 and soluble thrombomodulin were upregulated in ex vivo tissue culture of injured mouse skin. 3,4-Dichloroisocoumarin inhibited thrombomodulin production and wound healing; this was reversed by recombinant thrombomodulin in mice. PMID:21833011
21. Mutations in Thrombomodulin is associated with metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. PMID:21788337
22. During cardiac hypertrophy, thrombomodulin treatment decreases cardiomyocyte apoptosis and maintains left ventricular contractile function in response to pressure overload. PMID:21111988
23. Thrombomodulin and platelet-derived growth factor receptor alpha (PDGFRalpha) identify a population of fibroblastic reticular cells in lymph nodes where chemokine secretion is controlled by junction adhesion molecule 3 protein (JAM-C). PMID:21685324
24. Paclitaxel downregulates thrombomodulin expression in aortic endothelial cells. PMID:21423464
25. Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin. PMID:20348393
26. lectin-like domain of TM interferes with polymorphonuclear leukocyte adhesion to ECs by intercellular adhesion molecule 1-dependent and -independent pathways through the suppression of extracellular signal-regulated kinase activation PMID:12208873
27. These findings show a new function for the thrombomodulin-protein C system in controlling the growth and survival of trophoblast cells in the placenta, which is essential for the maintenance of pregnancy. PMID:12579195
28. Deficiency in TM results in enhanced thrombus formation in a murine model of carotid artery thrombosis and support a role for TM defects in arterial thrombotic disease PMID:14556079
29. thrombomodulin generates activated protein C but does not play a role in the pulmonary response to respiratory pathogens or lipopolysaccharide PMID:14592828
30. thrombomodulin has an antimetastatic role in reducing cell proliferation and enhancing Ca2+-independent cell aggregation PMID:15448005
31. surviving Thrombomodulin activated protein C generation mice displayed increased lung inflammation accompanied by higher mycobacterial loads in liver and spleen PMID:16014564
32. analysis of the role of TM in modulating innate immunity PMID:16879225
33. peripheral clock in vascular endothelial cells regulates TM gene expression and that the oscillation of TM expression may contribute to the circadian variation of cardiovascular events PMID:17848551
34. Par4 deficiency of the mother, or the absence of maternal platelets, restores normal development in one-third of Thbd-null embryos PMID:18490515
35. the lectin-like domain of thrombomodulin protects against ischaemia-reperfusion lung injury PMID:18508817
36. Ets-1 mediates platelet-derived growth factor-BB-induced thrombomodulin expression in human vascular smooth muscle cells. PMID:19091791

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UNIGENE: Mm.24096

KEGG: mmu:21824

STRING: 10090.ENSMUSP00000096877