Recombinant Mouse T-cell surface glycoprotein CD4 (Cd4)

1. data showed the critical role of the first extracellular domain of CD4, by obtaining mice with a loss of function mutation from Ile to Asn at the position 99 of CD4 (I99N). PMID:29028486
2. results suggest that CD4 CD8 double knockout (DN)T cells can develop efficiently in vivo and chronic exposure to bacterial superantigens may precipitate a lupus-like autoimmune disease through activation of DNT cells PMID:28468970
3. TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells. PMID:25536344
4. High-fat diet - induced type 2 diabetes decreases the number of ileum IL17/RORgammaT CD4 T cells. PMID:26154056
5. Results indicate that hypomethylation of Cd4 antigen correlates with stable CD4 expression. PMID:26030024
6. CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck PMID:25829544
7. This study establishes an important role of IgE in abdominal aortic aneurysms pathogenesis by activating CD4+ T cells, mast cells, and macrophages. PMID:24963147
8. 5-kb cis-element is required in postselection thymocytes for helper lineage commitment, presumably mediating the maintenance of CD4 expression, and suggest that inactivation of the cis-element by DNA methylation PMID:24729613
9. Both type I CD8+ cytotoxic (Tc1) cells and interleukin (IL)-17-producing CD8+ (Tc17) cells mediate effective antitumor immunity through distinct effector mechanisms, but Tc1 cells are superior to Tc17 cells in mediating tumor regression. PMID:23315072
10. Accumulation of CD4 positive effector T cells is a critical step in the progression from mild glomerulonephritis to severe crescentic glomerulonephritis accompanied by tubulointerstitial inflammation and loss of kidney function. PMID:22437418
11. Thymic selection does not appear to play an important role in CD4+CD8+ T cell receptor (TCR)beta repertoire overlap between individuals. PMID:22826324
12. CD4-positive cell deficiency impairs IFN-gamma production by CD8-positive effector cells at the site of Mycobacterium tuberculosis infection in mice. PMID:22837486
13. galectin-1 inhibition reduces murine lung metastasis with increased CD4(+) and CD8 (+) T cells and reduced cancer cell adherence PMID:22484915
14. Mice that lack the ability to make both CD8-positive and CD4-positive induced regulatory T (iTreg) cells have accelerated graft-vs-host-disease mortality compared with animals that are competent to make both iTreg populations. PMID:22649199
15. Danazol induced prolonged cardiac allograft survival and generation of regulatory CD4(+) cells. PMID:22564626
16. Hepatic stellate cells seem to act as liver-resident antigen-presenting cells instructing the generation of CD4/CD25/Foxp3(+) regulatory T cells. PMID:22564624
17. Thymic or peripheral CD4+ Foxp3+ regulatory T cells cells manifest prominent functional plasticity and readily reprogram into Th1 and Th17 effector cells, particularly in the gut microenvironment or sites of parasitic infection. PMID:22545118
18. Both CD4(+) and CD8(+) regulatory T cells appeared to be protective against Graft vs Host Disease - induced lethality and required IL-2 and TGF-beta receptor expression for their generation. PMID:22496155
19. SR-A knockout (SR-A(-/-)) mice developed a more robust Cd4(+) T cell response than wild-type mice after ovalbumin immunization. PMID:22083206
20. CD4+FoxP3+ regulatory T cells from Galphai2-/- mice are functionally active in vitro, but do not prevent colitis PMID:21966415
21. GITR is not required on the surface of CD4-positive T-cells to induce colitis in mice. Knockout mice develop aggravated chronic enterocolitis via an imbalance of colitogenic Th1 cells and Treg cells. PMID:22155173
22. leflunomide has an effect on CD4(+)CD25 (+)Foxp3 (+) T regulatory cells in mice receiving allogeneic bone marrow transplantation PMID:22057872
23. The average percentage of CD154 expression among CD4+ FoxP3+ T regulatory (Treg) cells was only about 4-9%. PMID:21496498
24. AP4 contributes to Cd4 silencing both in DN and CD8(+) T cells by enforcing checkpoints for appropriate timing of CD4 expression and its epigenetic silencing. PMID:21873191
25. HMGB1 has the ability to directly modulate the suppressive capacity of CD4(+)CD25(+)Tregs, and TLR4 might be a potential receptor essential for the negative effect of HMGB1 on CD4(+)CD25(+)Tregs activity PMID:21419643
26. aged CD4+ T cell function impairment is intimately related to multiple alterations in aged DCs, rather than being caused solely by intrinsic T cell defects PMID:21453718
27. Small intestine CD11c+ CD8+ T cells suppress CD4+ T cell-induced immune colitis. PMID:21436315
28. Data show that CD8(+) T cell tolerance established in the lung depends only partially on the function of CD4+CD25+Foxp3+ regulatory T cells. PMID:21518973
29. anti-TIM3 requires IFN-gamma producing CD8(+) T cells and CD4(+) T cells, and a higher ratio of tumor infiltrating CD8(+):CD4(+) T cells correlating with therapeutic success PMID:21430066
30. Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4+CD25+ regulatory T cells PMID:21170379
31. Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells PMID:20639459
32. Astragalus membranaceus injection prolonged allograft survival associated with promotion of CD4+ CD25+ Treg activities. PMID:21094858
33. Results suggest that CD4+CD25+ Treg cells directly affect cisplatin nephrotoxicity and their modulation represents an additional treatment strategy. PMID:20463654
34. Cotransfer of CD8-positiveCD122-positive regulatory T cells (Tregs) clearly suppresses development of colitis, a synergistic effect similar to that of CD4-positiveCD45RB(low) cells that are mostly CD4-positive Tregs. PMID:21098236
35. T-cell receptor stimulation of HTLV-1 LTR-Tax transgenic CD4+ T cells induced Tax expression, hyper-proliferation, and immortalization in culture. PMID:20634377
36. impairment of Lck-mediated CD4 coreceptor signaling by Nef is an important in vivo mechanism of HIV-1 pathogenesis PMID:20826747
37. Pulmonary CD11c+ cells are critical for NO2-promoted allergic sensitization via antigenspecifici CD4+ T-cell polarization. PMID:20659336
38. Data describe why ibalizumab has not had adverse immunological consequences in infected patients but also raise possible steric hindrance mechanisms by which this antibody blocks HIV-1 entry into a CD4-positive cell. PMID:20463063
39. This significant intracellular storage of LAG-3 appears to facilitate its rapid translocation to the cell surface following T-cell activation, which was much faster for LAG-3 than CD4 PMID:20391435
40. Immunosuppressive agents could be successfully combined with in vitro-expanded CD4+CD25+Foxp3+Treg cell therapy to prevent allograft rejection. PMID:20305583
41. the proximal enhancer (E4(P)) of Cd4 is essential for CD4 expression in immature CD4(+)8(+) thymocytes PMID:20360383
42. Flt3-L significantly inhibited the effect of cockroach antigen sensitization and challenge to increase GATA3 expression in lung CD4(+)CD25(+) T cells. PMID:19448155
43. CD4 modulates activity of T cells that express an intermediate affinity, histocompatibility class-I restricted T cell receptor. PMID:19923452
44. These results indicate that CD4+CD25+Foxp3+ Tregs modify innate immune responses during resolution of lung injury and suggest potential targets for treating acute lung injury. PMID:19770521
45. Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells PMID:19759824
46. miR-155 is shown to be crucially involved in nTreg cell mediated tolerance by regulating the susceptibility of conventional human as well as murine CD4(+) Th cells to nTreg cell-mediated suppression PMID:19777054
47. the effects of Deletion of the CD4 silencer element on thymocyte lineage was examined PMID:11694883
48. An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis. PMID:11908949
49. Relationship between CD34 expression and CD4 expression by hematpoietic stem cells and their long-term reconstitution capability. PMID:11937272
50. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice: implications for the nonredundant function of IL-2 PMID:12196288

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UNIGENE: Mm.2209

KEGG: mmu:12504

STRING: 10090.ENSMUSP00000024044