Recombinant Mouse T-cell surface antigen CD2 (Cd2)

1. Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes PMID:26438525
2. CD2 stimuli were mandatory for Treg cell survival with reduced Bim expression, but CD2 may not function as a direct receptor for molecules on stromal cells. PMID:23278598
3. CD2 is important for the efficient development of CD4 single-positive thymocytes and TCR-dependent activation of mature CD4 lymph node T cells, but does not direct a particular helper T cell subset polarity. PMID:11801645
4. This antigen is a dominant target for heart allograft responses. PMID:12201362
5. molecular mechanism of heterophilic adhesion between the murine T-cell adhesion glycoprotein CD2 and its ligand CD48 PMID:12356317
6. Despite normal T cell numbers, mice deficient in the costimulatory molecules CD2 and CD28 spontaneously develop Pneumocystis carinii pneumonia. PMID:12902500
7. autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster PMID:15589166
8. Analysis of the ligand-receptor pairs involved in induction of germline transcripts (Igamma2a) necessary for switch recombination revealed that expression of CD48 on B cells and ligands CD2 and CD244 on NK cells are able to stimulate Igamma2a PMID:15778370
9. CD2 deficient mice are more resistant to T. gondii infection than wild type mice PMID:17696249
10. nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse PMID:18826951
11. CD244 inhibition and activation depends on CD2 and phospholipase C-gamma1 PMID:19586919

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UNIGENE: Mm.22842

KEGG: mmu:12481

STRING: 10090.ENSMUSP00000029456