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Recombinant Mouse T-cell immunoreceptor with Ig and ITIM domains (Tigit)

Recombinant Mouse T-cell immunoreceptor with Ig and ITIM domains (Tigit)

CSB-CF023545MO

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20μg100μg

US$4148

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Express system: in vitro E.coli expression system

Species: Mus musculus (Mouse)

Tag Info: N-terminal 10xHis-tagged

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Target Background

Product Details

Target Names

Tigit

Uniprot NO.

P86176

Species

Mus musculus (Mouse)

Source

in vitro E.coli expression system

Expression Region

29-249

Target Protein Sequence

TIDTKRNISAEEGGSVILQCHFSSDTAEVTQVDWKQQDQLLAIYSVDLGWHVASVFSDRVVPGPSLGLTFQSLTMNDTGEYFCTYHTYPGGIYKGRIFLKVQESSDDRNGLAQFQTAPLGGTMAAVLGLICLMVTGVTVLARKDKSIRMHSIESGLGRTEAEPQEWNLRSLSSPGSPVQTQTAPAGPCGEQAEDDYADPQEYFNVLSYRSLESFIAVSKTG

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 10xHis-tagged

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Description

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Target Background

Function

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Database Links

UNIGENE: Mm.390896

STRING: 10090.ENSMUSP00000093770

Recombinant Mouse T-cell immunoreceptor with Ig and ITIM domains (Tigit)

Product Details

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Target Background