Recombinant Mouse Podoplanin (Pdpn)

1. mouse podoplanin initiates the formation of stable platelet aggregates at high shear. We speculate that this is important during the development of the mouse cerebrovasculature triggered by podoplanin on neuroepithelial cells and represents a specialized form of hemostasis. PMID:29090616
2. Results suggest podoplanin-CLEC-2 as a novel anti-inflammatory axis regulating immune cell recruitment and activation in sepsis. PMID:29269852
3. TGF-beta release from platelets is necessary for podoplanin-mediated tumor invasion and metastasis in lung cancer. PMID:28176852
4. study uncovers a role for Pdpn in mammary SC function and, importantly, identifies Pdpn as a new regulator of Wnt/beta-catenin signaling, a key pathway in mammary development and tumorigenesis. PMID:29361573
5. these data suggest that the platelet CLEC-2-podoplanin signaling axis regulates the severity of lung inflammation in mice and is a possible novel target for therapeutic intervention in patients at risk of developing ARDS. PMID:28839100
6. Describe a bone-specific conditional Pdpn hypomorphic knockout mouse and confirm a role for Pdpn in the attainment of fully elongated osteocyte dendrites. PMID:28488815
7. In podoplanin conditional knockout mice (Wnt1-Cre;PdpnDelta/Deltamice), the tooth and alveolar bone showed no morphological abnormalities and grow normally, indicating that podoplanin is not critical in the development of the tooth and bone. PMID:28222099
8. Podoplanin expressed by lymphatic vessels prevents postnatal blood filling of the lymphatic vascular system and contributes to efficient dendritic cell migration to the lymph nodes. PMID:27810998
9. Study provides evidence that podoplanin as a novel component of the neuronal machinery underlying neuritogenesis, synaptic plasticity, and hippocampus-dependent memory functions. PMID:27558977
10. This study suggests that ppGalNAc-T13 contributes to neuronal differentiation through glycosylating and stabilizing PDPN, which provides insights into the regulatory roles of O-glycosylation in mammalian neural development. PMID:27629416
11. A reciprocal interaction between CLEC-2 on megakaryocytes and PDPN on Bone marrow (BM) Fibroblastic reticular cell-like cells contributes to the periarteriolar megakaryopoietic microenvironment in mouse BM. PMID:26796360
12. Data indicate that a mechanism reliant upon blockade of proteasome-mediated E11 destabilization contributes to osteocytogenesis and that this may involve downstream targeting of RhoA. PMID:26639105
13. it is likely that PDPN, while being dispensable during re-epithelialization, has a crucial role in migration and invasion of transformed keratinocytes. PMID:26121181
14. Report distinct podoplanin-positive stromal cell populations and a novel progenitor subset in chronic liver inflammation and fibrosis. PMID:26564718
15. CLEC-2 is an adhesive receptor that supports platelet arrest to podoplanin under venous shear. Src/Syk-dependent signalling stabilises platelet adhesion to podoplanin. PMID:25694214
16. Alternative NF-kappaB signaling regulates mTEC differentiation from podoplanin-expressing presursors in the cortico-medullary junction. PMID:25973789
17. These results provide new insight into PDPN phosphorylation dynamics and the role of PDPN in cell motility. PMID:25959509
18. Podoplanin and CLEC-2 critically drive the formation and integrity of developing cerebral blood vessels. PMID:25908104
19. DC-derived LTBR ligands are critical mediators of lymph node cells survival, and LTBR signaling on reticular stromal cells is mediated by Pdpn expression. PMID:25902483
20. PDPN functions as an inhibitory molecule on T cells, thereby promoting tissue tolerance by limiting long-term survival and maintenance of CD4+ effector T cells in target organs. PMID:25415436
21. CLEC-2 signaling promotes adhesion to Podoplanin and regulation of Podoplanin signaling, thereby contributing to lymphatic vasculature development. PMID:25368330
22. Podoplanin regulates actomyosin contractility in fibroblastic reticular cells. PMID:25347465
23. The results of this study confirm that expression of PDPN is part of the normal host response to brain injury and gliomas. PMID:25470350
24. These data indicate that sialylated O-glycans of PDPN are essential for platelet adhesion and prevent PDPN from proteolytic degradation primarily mediated by MMPs in the lymph. PMID:25336627
25. These data suggest that the function of Pdpn in lymphangiogenesis does not depend on threonine 34 in the CLEC-2 binding domain and that PdpnT34A-Fc might be an improved inhibitor of lymphangiogenesis with fewer toxic side effects. PMID:24907275
26. knock-out mice diosplay delayed T regs differentiation PMID:23912054
27. local sphingosine-1-phosphate release after PDPN-CLEC-2-mediated platelet activation is critical for high endothelial venules integrity during immune responses PMID:23995678
28. PKA can phosphorylate PDPN to decrease cell migration. PMID:23530051
29. podoplanin would be a useful Th17 cell marker for diagnosing pathological conditions of autoimmune diseases, including rheumatoid arthritis. PMID:23287598
30. a lectin from the seeds of Maackia amurensis (MASL) with affinity for O-linked carbohydrate chains containing sialic acid targets PDPN to inhibit transformed cell growth and motility PMID:22844530
31. activation of CLEC-2 by PDPN rearranges the actin cytoskeleton in dendritic cells to promote efficient motility along stromal surfaces. PMID:22884313
32. Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma PMID:21801875
33. A transmembrane glycoprotein, gp38, is a novel marker for immature hepatic progenitor cells in fetal mouse livers. PMID:21104040
34. Immunogenicity of a chemoenzymatically produced Tn-glycopeptide derived from the putative murine podoplanin O-glycopeptide epitope, was investigated. PMID:20721622
35. Pdpn positive cells are involved in lymphangiogenesis and lymphatic vasculogenesis. PMID:20855662
36. podoplanin was expressed on a subset of F4/80(+) macrophages; a subset which was termed fibroblastic macrophages during zymosan peritonitis. PMID:20682314
37. A nonhemostatic pathway in which platelet CLEC-2 receptors bind lymphatic endothelial PDPN and activate SLP-76 signaling to regulate embryonic vascular development. PMID:20363774
38. Loss of podoplanin is asociated with non-separation of blood and lymphatic circulation. PMID:20110424
39. SRC induces podoplanin expression to promote cell migration PMID:20123990
40. findings show that adult LTi-like cells require extrinsic signals from podoplanin(+) splenic stromal cells to survive and suggest that IL-7 is not necessary to mediate their survival in the adult spleen. PMID:19950181
41. T1alpha and caveolin-1 are located in distinct plasma membrane microdomains, which differ in their protein-lipid interactions. PMID:20054149
42. cloning and expression in the mouse glomerulus PMID:12032185
43. in the absence of T1alpha protein, lung alveolar epithelial type I cell differentiation is blocked, as indicated by smaller airspaces, many fewer attenuated type I cells, and reduced levels of aquaporin-5 mRNA and protein PMID:12654292
44. The role of T1a in vascular development and the effects of gene disruption in mice were studied. In cultured endothelial cells T1a promotres cell adhesion, cell movement and tube formation. PMID:12853470
45. RANDAM-2 nucleotide sequence completely matched that of PA2.26 antigen. RANDAM-2 is one of the type I membrane surface antigens constitutively expressed on undifferentiated neuronal cells and the glutamatergic neuronal cells during mouse neurogenesis PMID:12929128
46. Expression of Aggrus induced platelet aggregation without requiring plasma components. The highly conserved platelet aggregation-stimulating domain was identified. PMID:14522983
47. podoplanin induces an alternative pathway of tumor cell invasion in the absence of epithelial-mesenchymal transition PMID:16616332
48. Freshly isolated primary osteoblasts are negative for E11 expression but begin to express this protein in culture, and expression increases with time, suggesting differentiation into the osteocyte phenotype. PMID:16738320
49. T1alpha may play a role in normal lung morphogenesis; mice lacking lung differentiation gene T1alpha fail to form expanded alveolar sacs, resulting in respiratory failure at birth. PMID:16869965
50. findings show wild-type protein could be transformed into a tumor-specific antigen; a somatic mutation in Cosmc gene abolished function of a glycosyltransferase disrupting O-glycan Core 1 synthesis & creating a tumor-specific glycopeptidic neo-epitope PMID:17038624

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UNIGENE: Mm.2976

KEGG: mmu:14726

STRING: 10090.ENSMUSP00000030317