Recombinant Mouse P-selectin (Selp)

1. In a laser injury-induced thrombosis model, P-selectin modulates thrombus propagation independently of VWF and TSP1 PMID:27943541
2. deletion of P-sel disrupted megakaryocyte/neutrophil interactions in spleen, reduced TGF-beta content, and corrected the hematopoietic stem cells distribution that in Gata1(low) mice, as in primary myelofibrosis patients, is abnormally expanded in spleen. PMID:26439305
3. The present study supported the notion that CD62P accumulation during platelet storage is involved in mediating transfusion-related acute lung injury. PMID:26397744
4. Holothurian glycosaminoglycan has emerged as a novel anti-cancer agent via blocking P-selectin-mediated malignant events of tumor metastasis. PMID:26318439
5. Data (including data from studies in transgenic mice) suggest that sequence variations limited to 1.4-kb proximal promoter region account for most differences in expression of murine Selp and human SELP genes. PMID:26631722
6. P-selectin has a role in endothelial progenitor cells' inhibition of platelet function PMID:25948279
7. Both platelet and endothelial cell P-selectin contribute to host defense during Klebsiella pneumosepsis. PMID:25773400
8. Platelet infiltration into solid tumors occurs through a P-selectin-dependent mechanism and promotes tumor growth. PMID:25762641
9. P-selectin promotes neutrophil extracellular trap (NET) formation and is a potential target for NET-related diseases. PMID:25979951
10. P-selectin is an important adhesion molecule vital for infiltration of regulatory T cells into mouse mammary tumors PMID:25865803
11. Administering human recombinant PTX3 to wild-type mice induced endothelial dysfunction and increased blood pressure, an effect absent in P-selectin-deficient mice. PMID:25747934
12. Targeting P-selectin-mediated platelet adhesion onto endometriotic lesions holds promise as a novel therapeutics for treating endometriosis. PMID:25681855
13. Endothelial peroxisome proliferator-activated receptor-gamma protects against thrombosis through a mechanism that involves downregulation of P-selectin expression and diminished P-selectin-mediated leukocyte-endothelial interactions. PMID:25675995
14. These results demonstrate that chronically raised sP-selectin favours progression of an unstable atherosclerotic plaque phenotype. PMID:24846287
15. P-selectin-mediated platelet adhesion promotes the metastasis of murine melanoma cells. PMID:24632801
16. (68)Ga-Fucoidan represents a versatile imaging biomarker for P-selectin with the potential to specifically detect P-selectin expression using positron emission tomography and to discriminate vulnerable plaques in vivo. PMID:24903095
17. The ability of ascorbate to reduce platelet aggregation and P-selectin expression could be an important mechanism by which ascorbate inhibits capillary plugging in sepsis. PMID:23402318
18. These experiments define a novel VEGF-miR-1-Mpl-P-selectin effector pathway in lung Th2 inflammation and herald the utility of miR-1 and Mpl as potential therapeutic targets for asthma. PMID:24043765
19. These results demonstrated the ability for Abeta to enhance p-selectin expression at the cerebral endothelial cell surface and induce cytoskeleton reorganization. PMID:23593361
20. Expression of P-selectin is sufficient to support rescue & hematopoietic reconstitution of lethally irradiated recipients forllowing bone marrow transplant. PMID:23499761
21. These results suggest that AT1A signaling plays a critical role in tumor metastasis through P-selectin-mediated interactions of platelets with tumor and endothelial cells. PMID:23219751
22. Older animals had significantly larger venous thrombi versus younger animals post-thombosis, as a result of high levels of P-selectin both in the circulation and locally at the level of the vein wall. PMID:23174624
23. P-selectin is a candidate target molecule for early-phase detection by PET and CT fusion imaging of atherosclerotic plaques. PMID:23485468
24. our findings help clarify the roles of platelets, NK cells and P-selectin in metastasis PMID:22836751
25. the first evidence for P-selectin upregulation by persistent mCMV infection and implicate this adhesion molecule in the associated arteriolar dysfunction. P-selectin PMID:21457388
26. Loss of CD63 has a similar phenotype to loss of P-selectin itself, thus CD63 is an essential cofactor to P-selectin. PMID:21803846
27. Data show that Tpst1/Tpst2 DKO leukocytes bound less P-selectin than wild type leukocytes despite equivalent surface expression of Psgl-1. PMID:21633705
28. Demonstrate a profound estrogen-dependent suppression of leukocyte recruitment in females via reduced endothelial P-selectin expression. PMID:21350195
29. P-selectin and E-selectin mediate recruitment of reperfusion-induced bone marrow stromal cells to the infarct site, thereby enabling their adhesion to the postischemic cerebral microvasculature. PMID:21257828
30. Findings reveal functionally significant differences in basal and inducible expression of human and murine P-selectin in vivo. PMID:21149548
31. P-selectin is important in host innate immune response against Citrobacter infection. PMID:20345490
32. Suggest that platelet binding activates neutrophils and contributes to a chronic inflammatory state and pulmonary dysfunction in sickle cell disease via P-selectin. PMID:21071696
33. P-selectin-deficient allo-bone marrow transplant recipients are resistant to the development of graft-versus-host disease (GVHD), which suggests that P-selectin of recipient origin is an important molecule for GVHD pathophysiology. PMID:20622117
34. Results reveal an intracellular WPb-independent P-selectin pool in pulmonary capillary endothelium, where the regulated P-selectin surface expression is triggered by Ca(2+) transients evoked through activation of the alpha(1G) T-type channel. PMID:20435690
35. Platelet, not endothelial, P-selectin contributes to generation of immunity in 2,4,-dinitrofluorobenzene-induced contact hypersensitivity. PMID:20056837
36. P-selectin and P-selectin glycoprotein ligand 1 are dominating molecules in supporting adhesive interactions of CD8 T cells in inflamed colonic venules PMID:19730132
37. Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow. PMID:19666063
38. PL-selectin double deficient mice show that the two selectins work synergistically. PMID:11854515
39. P-selectin may be a key target to reduce pathological recruitment of inflammatory cells in the colon. PMID:11934816
40. The N-terminal peptide of PSGL-1 can mediate adhesion to trauma-activated endothelium via P-selectin in vivo. PMID:12091345
41. The role of P-selectin overlaps that of alpha 4 integrin in mediating leukocyte-endothelial cell interactions during experimental autoimmune encephalomyelitis. PMID:12097407
42. P-selectin is incolved in the development of Con A-induced liver injury and reveal the protective effect of blocking P-selectin in this hepatitis. PMID:12149416
43. Early CNS migration of a CD4 Th1 cell line was facilitated by P selectin in (PL/JxSJL/J)F1 mice. Genetically determined kinetics of immune surveillance may regulate the phenotype of subsequent CNS inflammation. PMID:12161020
44. platelet P-selectin is required for monocyte infiltration during neointima formation in injured carotid arteries of apoE-/- mice PMID:12234959
45. The migration of in-vitro generated cytotoxic T lymphocytes into inflamed skin is partially mediated by P-selectin. PMID:12370362
46. A dysfunctional immune response in P-selectin knockout mice lacking also E-selectin results from impaired leukocyte trafficking and leads to chronic ulcerative dermatitis. PMID:12391189
47. data suggest that sulfation of Tyr13 and O-glycosylation of Thr17 are necessary for murine PSGL-1 to bind optimally to P-selectin PMID:12393631
48. endothelial P-selectin is critical for postischemic platelet-endothelial cell interactions within hepatic presinusoidal arterioles and postsinusoidal venules. P-selectin deficiency prevents microvascular injury and apoptosis after warm hepatic I/R PMID:12462561
49. the role of platelet versus endothelial P-selectin in generating sP-selectin and in the formation of atherosclerotic lesions PMID:12480714
50. P-selectin-mediated leukocyte-rolling velocity is stabilized by leukocyte deformation during rolling that offsets increased bond breakage at higher shear stress PMID:12483549

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UNIGENE: Mm.3337

KEGG: mmu:20344

STRING: 10090.ENSMUSP00000123924