Recombinant Mouse Muscarinic acetylcholine receptor M4 (Chrm4)

1. The findings of this study indicated that the cocaine-like S(D) effects of muscarinic antagonists are primarily mediated through M1 receptors, with a minor contribution of M4 receptors. PMID:28442355
2. In the present study, the functional coupling of Gi/o protein-coupled receptors to GalR1, and the CB1 receptor subtype for endocannabinoids were analyzed in the 3xTg-AD mice model of Alzheimer's disease in the prodromal and advanced stages. In addition, the activity mediated by Gi/o protein-coupled M2/4 muscarinic receptor subtypes was also analyzed in brain areas involved in anxiety and cognition. PMID:27223629
3. Muscarinic acetylcholine receptor subtype 4 is essential for cholinergic stimulation of duodenal bicarbonate secretion in mice - relationship to D cell/somatostatin PMID:26084221
4. Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic Huntington's disease - YAC128 mice. PMID:26508634
5. the role of the M4 receptor in alcohol consumption PMID:25445043
6. We show that M4 is a major mAChR subtype mediating the cholinergic inhibition of corticostriatal glutamatergic input on both striatonigral and striatopallidal medium spiny neurons (MSNs). PMID:24528004
7. The characterization of the orthosteric agonist, iperoxo, at the M(4) receptor. PMID:24807965
8. These data support a role for the M4AChR subtype in mediating the antipsychotic-like activity of BuTAC. PMID:23907402
9. Presence of M4 mAChR is sufficient and necessary to mediate the carbachol-induced membrane hyperpolarization and inhibition of SpECTs in laterodorsal tegmental nucleus neurons. PMID:22956788
10. M4R is involved in regulation of locomotor activity, social behavior, and sensorimotor gating in mice. PMID:22463818
11. Reducing M4 receptor signaling altered only select behavioral phenotypes in the Fmr1KO mouse model, suggesting that other targets are involved in the modulation of fragile X behaviors. PMID:22123412
12. Chrm4 receptor is located on presynaptic glutamatergic terminals afferent to the recorded pyramidal neuron, thus decreasing glutamate release. PMID:20600670
13. The muscarinic M(4) receptor is the functionally predominant subtype in mouse striatum. PMID:21114972
14. Different coupling of striatal M(2)/M(4)-mAChRs to the control of DA release in CPu versus NAc suggests targets to influence DA/ACh function differentially between striatal domains. PMID:20203199
15. a distinct subpopulation of neuronal M(4) mAChRs plays a critical role in modulating several important dopamine-dependent behaviors. PMID:20147565
16. muscarinic analgesia is exclusively mediated by a combination of M(2) and M(4) mAChRs at both spinal and supraspinal sites. PMID:12391271
17. M(4) mAChR plays a central role in mediating cholinergic control of keratinocyte migration by endogenous acetylcholine produced by these cells PMID:12628458
18. M4 mAChRs modulate dopamine activity in motor tracts and act as inhibitory autoreceptors in striatum. Review. PMID:12675128
19. There is a crucial role for M4 receptors in the tonic and phasic regulation of acetylcholine efflux in the hippocampus as well as in cognitive processes. The M4 receptor participates in a tonic regulatory loop contolling basal acetylcholine levels. PMID:12874603
20. loss of M4 muscarinic receptor control of cholinergic function effectuates a state of dopaminergic hyperexcitability PMID:15231726
21. M4 increases expression of "migratory" integrins; M4 effects resulted from inhibition of the inhibitory pathway involving the adenylyl cyclase-cyclic AMP-protein kinase A pathway PMID:15263021
22. This study indicate that both M4 mediate the muscarinic autoinhibition in ACh release in the longitudinal muscle with myenteric plexus preparation of the mouse ileum. PMID:15574798
23. M2 and M5 muscarinic receptors but not M4 muscarinic receptor or D2 dopamine receptors are needed for male USV production during male-female interactions PMID:18382674
24. Results suggest that GRK5 deficiency leads to a reduced hippocampal ACh release and cholinergic hypofunction by selective impairment of desensitization of presynaptic M2/M4 autoreceptors. PMID:19478075

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UNIGENE: Mm.330405

KEGG: mmu:12672

STRING: 10090.ENSMUSP00000040808