Recombinant Mouse Lysine-specific demethylase 6A (Kdm6a), partial

1. Lymphomas with low UTX expression express high levels of Efnb1, and cause significantly poor survival. PMID:30006524
2. Kdm6a expression improved the development of cloned mouse embryos by reducing H3K27me3 and increasing rDNA transcription. PMID:29239295
3. study provides a systematic screening of TSGs in vivo and identifies UTX as an important epigenetic regulator in lung tumorigenesis. PMID:29632194
4. UTX molecular function is in establishing appropriate chromatin structure to regulate crucial neural crest stem-cell signaling pathways. PMID:29073101
5. When JMJD3 levels were decreased by RNA interference, the embryo development rate and quality were improved, but the knockdown of UTX produced the opposite results. PMID:27384759
6. results reveal a previously unknown role of kdm6a in promoting innate IFN-beta gene transcription at enhancer, in addition to demethylation at promoter PMID:28284523
7. Long-term exposure to atmospheric particulates, PM2.5 up-regulated H3K4 and H3K9 methylation in IL-6 and IFN-beta promoter regions through down-regulating Kdm6a expression. The results suggest that short-term exposure to PM2.5 significantly enhances the survival rate of influenza A-contaminated mice, while long-term PM2.5 inhalation lowers the capacity of pulmonary macrophages to secrete IL-6 and IFN-beta. PMID:28887033
8. UTX-MLL4-p300 transcriptional regulatory network establishing an "active enhancer landscape" and defines a detailed mechanism for the joint deposition of H3K4me1 and H3K27ac. PMID:28732206
9. These results suggest that the demethylase activity of Jmjd3, but not that of Utx, affects mouse axial patterning in concert with alterations in Hox gene expression. PMID:28188179
10. Utx governs adipogenesis by regulating c-Myc in a differentiation stage-specific manner PMID:28319137
11. Ectopic expression of KDM6A antagonized TGF-beta-induced epithelial-mesenchymal transition and cell migration of lung cancer cells through its demethylase activity. PMID:28698146
12. this study reveals how UTX regulates the development of invariant natural killer T cells through multiple epigenetic mechanisms PMID:27992400
13. The results define UTX as a bivalency-resolving histone modifier necessary for stem cell differentiation PMID:26762983
14. Study demonstrated that the mammary luminal lineage relies on KDM6A to ensure a transcription program leading to differentiated alveoli. Failure to fully implement this program results in structurally and functionally impaired mammary tissue. PMID:27215382
15. differentiating embryonic stem cells (ESCs) depend on KDM6 and the H3K27me3 demethylase activity is crucially involved in DNA damage response and survival of differentiating ESCs. PMID:26759175
16. a critical role for the enzymatic activity of UTX in activating muscle-specific gene expression during myofiber regeneration and have revealed a physiological role for active H3K27 demethylation in vivo. PMID:26999603
17. Results propose that Utx plays important roles in osteoblast differentiation by controlling the expressions of Runx2 and Osterix. PMID:25920016
18. Utx is required for T-cell development. PMID:26328764
19. Genome-wide association between Six4, MyoD, and the histone demethylase Utx during myogenesis. PMID:26229056
20. Mice with a T-cell-specific UTX deletion had fewer Tfh cells, reduced germinal center responses, no virus-specific IgG, inability to resolve chronic LCMV infections, and decreased expression of IL-6-receptor-alpha and other Tfh cell-related genes. PMID:26431949
21. UTX may play a potential role in regulation of brown adipocyte gene expression PMID:26306033
22. Utx and Jmjd3 mutant mouse embryonic fibroblasts (MEFs) demonstrate dramatic loss of H3K27me3 from promoters of several Hox genes and transcription factors. PMID:25101834
23. Inhibition of histone demethylases UTX and JMJD3 inhibits HSV-1 reactivation from sensory neurons. PMID:25552720
24. H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia PMID:25320243
25. JMJD3 is essential for the initiation and maintenance of T-ALL, as it controls important oncogenic gene targets by modulating H3K27 methylation; by contrast, UTX functions as a tumour suppressor and is frequently genetically inactivated in T-ALL PMID:25132549
26. Utx is required for proper formation of ectoderm and mesoderm in vitro, and similar to its C.elegans homologue, has demethylase dependent and independent functions. PMID:23573229
27. Our study implicates Kdm6a, a gene that escapes X inactivation, in the regulation of genes important in reproduction, suggesting that KDM6A may play a role in the etiology of developmental and reproduction-related effects of X chromosome anomalies. PMID:23658530
28. UTX regulates stem cell migration and hematopoiesis. PMID:23365460
29. Our data suggest that UTX and UTY are able to regulate gene activity through demethylase independent mechanisms. PMID:23028370
30. Utx-null embryos had reduced somite counts, neural tube closure defects and heart malformation that presented between E9.5 and E13.5. PMID:22826230
31. identification of Utx as a novel mediator with distinct functions during the re-establishment of pluripotency and germ cell development PMID:22801502
32. Jmjd3 and UTX, mediate a functional interaction between the lineage-defining T-box transcription factor family and a Brg1-containing SWI/SNF remodeling complex. PMID:21095589
33. These results indicate that Rb and Rbl2 are downstream target genes of Utx and may play important roles in Utx-mediated cell growth control. PMID:20650264
34. The study shows a two-step mechanism for UTX-mediated demethylation of histone H3-Lys27 trimethylation (H3K27me3) at muscle-specific genes during myogenesis. PMID:20300060
35. Females are found to have significantly higher expression levels of Utx than males in most brain regions except the amygdala. PMID:18434530
36. Utx are markedly upregulated during murine skin repair. PMID:19575012
37. The JmjC domain-containing protein UTX specifically demethylates mono-, di- and trimethylated K27 of histone H3 in vitro. PMID:18003914
38. UTX associates with MLL3- and MLL4-containing histone H3 K4 methyltransferase complex(es) that also include ASH2L, RBBP5, WDR5, hDPY-30, PTIP, PA1, NCOA6. PMID:17500065

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UNIGENE: Mm.257498

KEGG: mmu:22289

STRING: 10090.ENSMUSP00000061539