Recombinant Mouse Lutropin-choriogonadotropic hormone receptor (Lhcgr)

1. Activating mutations in LHCGR cause familial male-limited precocious puberty PMID:28339861
2. Study tested for the first time a role of ZFP36L2 in the decay of LHR mRNA, when transcription was inhibited; results of our cell-based assay support the conclusion that LHR mRNA expression is controlled post-transcriptionally by ZFP36L2. PMID:28455422
3. FSHR and LHR proteins are significantly upregulated in CCs surrounding oocytes arrested at the 2-cell stage, reflecting their developmental incompetence. PMID:24476692
4. Triptorelin and cetrorelix induce immune responses and affect uterine development and expressions of genes and proteins of ESR1, LHR, and FSHR PMID:27075695
5. Data suggest that persistent cAMP signals from internalized luteinizing hormone receptor (LH receptors) contribute to transmitting LH effects inside follicle cells and ultimately to the oocyte. PMID:26828746
6. Demonstrate the presence of LH receptors. Activation resulted in a dose-dependent increase in glucose-induced release of insulin. PMID:25670721
7. LHCGR signaling in regulating the Ahr message involves protein kinase A pathway and is attributable to decreased transcription rate. PMID:24145128
8. Data from mutant mouse strain (gain-of-function mutation in LHR, D578G; most common mutation found in familial male-limited precocious puberty) confirm that LHR is critical for male steroidogenesis, gametogenesis, and Leydig cell development. PMID:23861372
9. LH/hCG tightly up-regulates MKP-3 which in turn, dephosphorylates ERK1/2 and drives p21 expression. PMID:23261984
10. Data suggest that Lhcgr in endometrium and luteinizing hormone in blastocyst are involved in embryo/blastocyst implantation; expression of Lhcgr is up-regulated in endometrial epithelium in estrus cycle at time of implantation readiness (estrus). PMID:23464498
11. Through the LHR, LH/hCG tightly regulates MKP-2 expression, which modulates the induction of CYP11A1 by 8Br-cAMP. PMID:23471219
12. Expression of LH receptor in nonpregnant mouse endometrium. PMID:22875961
13. Testicular CYP1B1 expression is regulated by LH through a PRKA-mediated pathway. PMID:21389345
14. Positive immunoreaction for LH receptors was present in the nuclei of urethral epithelium and endothelial cells of cavernous spaces in the corpus cavernosum and corpus spongiosum penis. PMID:20798391
15. Role of RXFP2 in mediating androgen-induced inguinoscrotal testis descent in LH receptor knockout mice. PMID:20154177
16. The study provides the first in vivo evidence linking the LH receptor, the EGFR, and ERK1/2 as sequential components of a pathway that regulates ovarian Cyp19a1 expression. PMID:20093417
17. Diminution of Abeta accumulation in the absence of LH receptor supports the contention that dysregulation of LH may impact the pathogenesis of Alzheimer disease. PMID:20142765
18. review of studies of Lhr expression and function using transgenic and knockout mouse models, including function as promoters of tumors PMID:11988311
19. review of knockout mice studies of the effect of inactivation of Lhr on phenotype PMID:11988312
20. Strain susceptibility to adrenocortical tumorigenesis (DBA/2J >> FVB/N) correlated with the expression of GATA-4 and LHR, implicating these factors in the process of adrenocortical neoplasia in response to continuous gonadotropin stimulation. PMID:12933687
21. Positive and reciprocal feed-forward amplification link between LHR and GATA-4 expressionleads to formation of the LH-dependent adrenocortical tumors. PMID:15256532
22. Lutropin and progesterone receptors exert distinct but coordinate effects on transactivation of the ADAMTS-1 gene in granulosa cells in vivo and in vitro PMID:15256533
23. In LH receptor knockout mice LH and CG control uterine functions directly as well as indirectly through increasing ovarian synthesis of steroid hormones. PMID:15836959
24. function of the extragonadal LHR using LHR-knockout mice, in which the ovaries of prepubertal mice were orthotopically replaced with pieces of wild type ovary PMID:15951841
25. activation of the endogenous lutropin/choriogonadotropin receptor (LHR) in mouse Leydig tumor cells leads to the tyrosine phosphorylation of the focal adhesion kinase FAK PMID:16293639
26. We propose that the LHR-mediated stimulation of the ERK1/2 cascade in Leydig cells depends on two independent pathways. PMID:17727840
27. The mRNA levels for several germ cell-specific proteins were up-regulated at 5 weeks of age in both WT and YHR(+) mice. PMID:19013498

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UNIGENE: Mm.1644

KEGG: mmu:16867

STRING: 10090.ENSMUSP00000024916