Recombinant Mouse Interleukin-13 receptor subunit alpha-2 (Il13ra2)

1. Upon lipopolysaccharide stimulation, macrophage Raw 264.7 cells showed elevated IL-13R-alpha-2 expression via immunofluorescence staining and increased MRI probe binding via built-in TAMRA fluorescence imaging. for the first time, IL-13R-alpha-2 was investigated as a unique biomarker in the context of osteomyelitis. PMID:28061526
2. Study presents evidence that PNR could promote ERalpha-negative breast cancer metastasis through activation of IL-13Ralpha2-mediated signaling pathway. PMID:24747967
3. overexpression of IL-13Ra2 inhibits the IL-13 induction of fibrotic markers in vitro and inhibits bleomycin-induced pulmonary fibrosis. PMID:25659898
4. data collectively support a distinct role for membrane IL-13Ralpha2 in the lung and suggest that memIL-13Ralpha2 might contribute to allergic inflammation PMID:23763980
5. When combined with IL-13Ralpha2 DNA cancer vaccine, Pseudomonas aeruginosa exotoxin A mediates synergistic antitumor effects on tumor growth and metastasis in established murine breast carcinoma and sarcoma tumor models. PMID:22013118
6. IL-13Ralpha2 serves a protective role in the pathogenesis of allergic inflammation and loss of skin barrier function in a mouse model of atopic dermatitis. PMID:20971924
7. studies illustrate the central role played by the IL-13Ralpha2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response PMID:12642601
8. IL-13 receptor alpha2 PMID:14652008
9. by suppressing IFN-gamma and up-regulating the decoy IL-13 receptor, P-selectin dramatically inhibits the pathologic tissue remodeling that results from chronic type 2 cytokine-mediated hepatic inflammation PMID:14999686
10. IL-13Ralpha2 is a selective and powerful inhibitor of IL-13-induced inflammatory, remodeling, and physiologic responses in the murine lung. PMID:18097054
11. Restoration of tumor immunosurveillance via targeting of interleukin-13 receptor-alpha 2. PMID:18451175
12. study concludes that matrix metalloproteinase-8 cleaves IL-13R alpha 2 in vitro and contributes to the solubilization of IL-13R alpha 2 in vivo PMID:18694590
13. Human and murine neuroendocrine pheochromocytoma overexpress the IL-13Ralpha2 chain, and an IL-13PE-based receptor-directed anticancer approach may prove useful in treatment for metastatic pheochromocytoma patients. PMID:19491224
14. IL-13Ralpha2 plays an important role in nematode infection by limiting the availability of IL-13 during infection, thereby regulating both the immune and biological effects of IL-13. PMID:19587021
15. IL-13Ralpha2 in macrophages may be a critical contributor to pathogenesis of schistosomiasis. PMID:19719966
16. Humans only express the membrane bound form of the IL-13 receptor alpha 2 PMID:18307523
17. The IL-13 receptor alpha 2 can be used to inhibit type-2 cytokine-mediated inflammation in the lung. PMID:9916716
18. A soluble form of the IL-13 receptor alpha 2 inhibited IL-13 activity and the progression of liver fibrosis in schistosomiasis. PMID:10491413
19. The IL-13 receptor alpha 2 suppresses granuloma formation, liver fibrosis, and portal hypertension in schistosomiasis and acts as a life-sustaining off signal for chronic and pernicious inflammation. PMID:14699044

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UNIGENE: Mm.368330

KEGG: mmu:16165

STRING: 10090.ENSMUSP00000033646