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Recombinant Mouse Interleukin-13 receptor subunit alpha-1 (Il13ra1)

Recombinant Mouse Interleukin-13 receptor subunit alpha-1 (Il13ra1)

Code: CSB-CF011591MO

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Size:

20μg100μg

US$5480

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Express system: in vitro E.coli expression system

Species: Mus musculus (Mouse)

Tag Info: N-terminal 10xHis-tagged

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Product Details
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Target Background

Product Details

Target Names

Il13ra1

Uniprot NO.

O09030

Alternative Names

Il13ra1; Il13r; Il13ra; Interleukin-13 receptor subunit alpha-1; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1; Interleukin-13-binding protein; Novel cytokine receptor 4; NR4; CD antigen CD213a1

Species

Mus musculus (Mouse)

Source

in vitro E.coli expression system

Expression Region

26-424

Target Protein Sequence

ATEVQPPVTNLSVSVENLCTIIWTWSPPEGASPNCTLRYFSHFDDQQDKKIAPETHRKEELPLDEKICLQVGSQCSANESEKPSPLVKKCISPPEGDPESAVTELKCIWHNLSYMKCSWLPGRNTSPDTHYTLYYWYSSLEKSRQCENIYREGQHIACSFKLTKVEPSFEHQNVQIMVKDNAGKIRPSCKIVSLTSYVKPDPPHIKHLLLKNGALLVQWKNPQNFRSRCLTYEVEVNNTQTDRHNILEVEEDKCQNSESDRNMEGTSCFQLPGVLADAVYTVRVRVKTNKLCFDDNKLWSDWSEAQSIGKEQNSTFYTTMLLTIPVFVAVAVIILLFYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHWKKYDIYEKQSKEETDSVVLIENLKKAAP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

Gene References into Functions

Chronic stress significantly reduced the number of substantia nigra dopaminergic neurons in Il13a1 knock-out mice. PMID:28427412
Delivery of sIL13ralpha1 to mice by either gene transfer or recombinant protein decreases blood glucose levels. Surprisingly, the glucose-lowering effect of sIL13ralpha1 was preserved in mice lacking IL-13, demonstrating that IL-13 was not required for the effect. In contrast, deletion of IL-4 in mice eliminated the hypoglycemic effect of sIL13ralpha1. PMID:28874358
findings indicate that NOD mice lacking the IL-4Ralpha/IL-13Ralpha1 heteroreceptor (HR) display resistance to Type 1 Diabetes as the rise in blood glucose level and islet inflammation were significantly delayed in these HR-deficient relative to HR-sufficient mice PMID:28646042
IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair. PMID:26153764
These results show that activation of IL-13Ralpha1 is critical for key aspects of the immune and functional responses to Hb2 infection that facilitate expulsion. PMID:26810038
CAR T cells killed IL13Ra1- and/or IL13Ra2-positive cells in contrast to IL13Ra1- and IL13Ra2-negative controls PMID:24841514
IL-13Ralpha1 is a surface marker for M2 macrophages influencing their differentiation and function. PMID:24281978
Expression of IL-13Ralpha1 on dopaminergic neurons can increase their susceptibility to oxidative stress-mediated damage, thereby contributing to their preferential loss. PMID:23169588
IL-13Ralpha1 is the key receptor mediating airway hypersensitivity responses, mucus production, and transforming growth factor (TGF)-beta induction in response to aeroallergens. PMID:21957151
The loss of IL-13Ralpha1 on islet-reactive T cells may be a biomarker for fading regional immune regulation and progression to overt diabetes. PMID:21617187
peaks of upregulation in allergic bronchial asthma at 6 hours and 3-12 hours after the last antigen inhalation PMID:20383033
Il13ra1-/- mice showed less mortality after infection with Schistosoma mansoni and more susceptibility to Nippostrongylus brasiliensis. IL-13Ralpha1 was essential for allergen-induced airway hyperreactivity and mucus hypersecretion. PMID:18066066
Differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity. PMID:18852293
IL-13R alpha 1 is required for allergen-induced airway hyperreactivity and mucus production but not for alternative macrophage activation. PMID:18066066