Recombinant Mouse Integrin beta-5 (Itgb5)

Code: CSB-CF011889MO

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Size:

20μg100μg

US$8294

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Express system: in vitro E.coli expression system

Species: Mus musculus (Mouse)

Tag Info: N-terminal 10xHis-tagged

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Product Details
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Target Background

Product Details

Target Names

Itgb5

Uniprot NO.

O70309

Alternative Names

Itgb5; Integrin beta-5

Species

Mus musculus (Mouse)

Source

in vitro E.coli expression system

Expression Region

24-798

Target Protein Sequence

GLNICTSGSATSCEECLLIHPKCAWCSKEYFGNPRSITSRCDLKANLIRNGCEGEIESPASSTHVLRNLPLSSKGSSATGSDVIQMTPQEIAVSLRPGEQTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLENIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILHGDSKNIIQLIINAYSSIRAKVELSVWDQPEDLNLFFTATCQDGISYPGQRKCEGLKIGDTASFEVSVEARSCPGRQAAQSFTLRPVGFRDSLQVEVAYNCTCGCSTGLEPNSARCSGNGTYTCGLCECDPGYLGTRCECQEGENQSGYQNLCREAEGKPLCSGRGECSCNQCSCFESEFGRIYGPFCECDSFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDVSTCKAKDGQICSDRGRCVCGQCQCTEPGAFGETCEKCPTCPDACSSKRDCVECLLLHQGKPDNQTCHHQCKDEVITWVDTIVKDDQEAVLCFYKTAKDCVMMFSYTELPNGRSNLTVLREPECGSAPNAMTILLAVVGSILLIGMALLAIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFAFNKFNKSYNGSV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Troubleshooting and FAQs

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Datasheet & COA

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Target Background

Function(From Uniprot)

Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.

Gene References into Functions

Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration PMID:24997346
Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. PMID:24036928
Phosphatidylserine-marked tips do not vary in mice lacking the diurnal phagocytic rhythm of the retinal epithelium due to loss of either alphavbeta5 integrin, or its extracellular ligand milk fat globule-EGF factor 8. PMID:22566632
Absence of RG2 does not affect the retinal architecture that requires alphavbeta5 integrins. PMID:22183400
Alphavbeta5 integrin is not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ dendritic cells. PMID:12055214
Integrin beta 5 knock-out mice demonstrated profoundly accelerated bone loss in the estrogene deplete state. PMID:15619670
analysis of the expression patterns of the alphavbeta3 and alphavbeta5 integrins in mouse developing gonads (10.5-13.5 days post coitum) showed that Beta5 integrin was localized in gonadal somatic cells, with the exception of coelomic epithelial cells. PMID:16571912
A function-blocking antibody against the integrin alphavbeta5 prevented development of lung vascular permeability in two different models of acute lung injury. PMID:17079779
beta5 integrin has a role in photoreceptor outer segment phagocytosis PMID:17249564
alpha(5)beta(1)-integrin is an important regulator of type I collagen production in early primary hepatic stellate cell (HSC) cultures but appears to have no direct role once the HSC are fully activated. PMID:17510195
MFG-E8 stimulates rhythmic photoreceptor outer segment fragments phagocytosis by ligating apical alphavbeta5 receptors of the retinal pigment epithelium. PMID:17620600