Recombinant Mouse Gonadotropin-releasing hormone receptor (Gnrhr)

1. leptin's direct stimulatory actions on gonadotrope GnRHR correlate with a direct inhibition of expression of the posttranscriptional regulator MSI1. There also is a direct MSI1 interaction with 3'-UTR of Gnrhr mRNA. PMID:29228137
2. the age-dependent basal and regulated Gnrhr transcription could account for the initial blockade and subsequent activation of the reproductive system during development. PMID:27569529
3. GnRH-GnRHR system is not essential for growth or motor/sensory/orientation behavior during the first month of life prior to puberty onset. The lack of the GnRH-GnRHR axis, however, did affect females resulting in reduced subcutaneous inguinal fat pad weight and increased glucose with possible insulin resistance. PMID:28346489
4. His305 of the GnRH receptor forms two distinct interactions that determine binding to GnRH and couple agonist binding to the conserved transmembrane domain network that activates GPCRs. PMID:25583361
5. Data confirm that Gnrhr mRNA and protein are expressed in ovaries, granulosa cells, cumulus cells, and oocytes. PMID:23913446
6. Msx1 functions as a negative regulator early in pituitary development by repressing the gonadotrope-specific alphaGSU and GnRHR genes. PMID:23371388
7. These results suggest decreased GnRH receptor signaling in the mutant animal, compared with wild type. PMID:22918878
8. GnRHR neurons were found in different brain areas. Many GnRHR neurons were identified in areas influencing sexual behaviors PMID:21303944
9. A comprehensive knowledgebase of the GnRHR signaling in the LbetaT2 cell, was curated. PMID:20592162
10. Null Gnrhr mice had small sexual organs, low levels of FSH, LH, and steroid hormones, failure of sexual maturation, infertility, and inability to respond to exogenous GnRH. PMID:20068010
11. GnRH and dex synergistically activate the endogenous GnRHR promoter in L beta T2 cells PMID:19812390
12. role of regulatory elements and their cognate transcription factors in transactivation of the mGnRHR gene PMID:12145309
13. an intact AP-1 element is necessary for GnRH responsiveness of the GnRHR gene; results suggest a critical role for JNK in mediating GnRH regulation of the GnRHR gene PMID:12586760
14. the GnRH receptor activating sequence is a composite regulatory element whose functional activity is dependent on the organization of a multi-protein complex consisting of Smads, AP-1 and a member of the forkhead family of DNA binding proteins PMID:12943993
15. Results suggest that pituitary homeobox 1 (Pitx-1) can direct transactivation of the mouse gonadotropin-releasing hormone receptor gene, in part by DNA binding and in part by an action of Pitx-1 as a cofactor for AP-1 [Pitx-1]. PMID:15226417
16. NF-Y and Oct-1 bind to the SURG-1 element to direct basal and GnRH-stimulated expression of the mGnRHR gene PMID:15388790
17. An autosomal-recessive mutation leucine to proline that causes hypogonadotrophic hypogonadism was isolated during an N-ethyl-N-nitrosourea mutagenesis screen in mice. PMID:15625238
18. Regulatory elements defined as the activin/TGFbeta-responsive "enhanceosome" were show in the promoter of the murine GnRHR gene. PMID:15637149
19. study demonstrates a functional role for LHX3 in the regulation of the GnRH receptor PMID:15705775
20. there are species-specific dominant negative receptor trafficking effects of the GnRHR between human, rat and mouse PMID:15886197
21. co-transfection of DAN markedly inhibited the synergistic activation of GnRH and activin on GnRH receptor gene expression thus implicating DAN as a novel autocrine/paracrine factor that modulates GnRH function in pituitary gonadotropes. PMID:17914181
22. These data implicate the clock genes as important factors controlling GnRHR expression in murine gonadotrope cells. PMID:17928134
23. We have defined the proportion of GnRHRs at the cell surface. PMID:18252959
24. NeuroD1 and Mash1 temporally regulate GnRH receptor gene expression in immortalized mouse gonadotrope cells. PMID:18760324
25. The two most proximal homeodomain-binding sites in the murine GnRHR promoter may regulate the promoter in a developmentally dependent fashion. PMID:19333792
26. Pulsatile and sustained gonadotropin-releasing hormone (GnRH) receptor signaling: does the Ca2+/NFAT signaling pathway decode GnRH pulse frequency PMID:19858197

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UNIGENE: Mm.26791

KEGG: mmu:14715

STRING: 10090.ENSMUSP00000031172