Recombinant Mouse Calcitonin receptor (Calcr)

1. Endosomal signaling of the CLR mediates pain transmission. PMID:29087309
2. calcitonin receptor is expressed in the suprachiasmatic nucleus and mediates body temperature fluctuations during the active phase in mice. PMID:29440246
3. Calcr knockout resulted in abnormal quiescent state of muscle stem cells, reduction of their pool apoptosis and relocation from the MSC niche. PMID:26440893
4. data suggest that Clr-b modulation is a conserved innate host cell response to virus infection that is subverted by multiple CMV immune evasion strategies. PMID:26044139
5. upregulated in synovial tissue of osteoarthritic mice by macrophage-derived IL-1 beta PMID:26400621
6. protects the maternal skeleton during lactation by a direct action on osteocytes to inhibit osteolysis PMID:26135836
7. Together, these data indicate that signaling through RAMP1 and CLR plays a role in mediating asthma pathology PMID:25010197
8. The relevance of the OPG/RANK/RANKL system in the particle-induced osteolysis process, was investigated. PMID:25486133
9. Nkrp1-Clr gene cluster appears to evolve more slowly relative to the related Ly49 cluster, and likely regulates innate immunosurveillance in a tissue-specific manner PMID:23226525
10. Odz4 is expressed in quiescent satellite cells, like calcitonin receptor, but the timing of the reappearance of these genes is different during regeneration. PMID:22562803
11. The perinatal expression of CTR within the ENS suggests that the calcitonin/CTR system may have a role in the maturation of enteric neurons PMID:22271140
12. CGRP-receptor component protein has been found to interact only with calcitonin-like receptor and represents a novel neuroendocrine regulatory step in calcitonin gene-related peptide signaling. PMID:22315449
13. CTR protects against hypercalcemia predominantly via its inhibitory action on osteoclasts. PMID:20850575
14. Data show that amylin inactivation leads to a low bone mass due to an increase in bone resorption, whereas bone formation is unaffected. PMID:14970190
15. Calcr is imprinted in a tissue-specific manner, with a predominant expression from the maternal allele in the brain PMID:12730726
16. Data show that mutation of calcitonin-like receptor did not affect its expression at the cell surface, but impaired the calcitonin gene-related peptide and adrenomedullin receptor function in the presence of receptor-activity-modifying proteins 1 and 2. PMID:15194494
17. CTR is not only down regulated by signaling through the CTR but also by the peptides signaling through calcitonin receptor-like receptor, and receptor activity modifying proteins PMID:18384073
18. These data provide strong evidence for a biological role of the CTR in regulating calcium homeostasis in states of calcium stress. PMID:18627265

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UNIGENE: Mm.4642

KEGG: mmu:12311

STRING: 10090.ENSMUSP00000075070