Recombinant Mouse CD44 antigen (Cd44)

1. this study shows that absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis PMID:29186109
2. this study demonstrates a new role for CD44 and hyaluronan in promoting alveolar macrophage survival PMID:29067996
3. CD44-positive proliferating glomerular cells, most likely parietal epithelial cells, are essential in the pathogenesis of scarring glomerular disease. PMID:29276101
4. We show here that cleavage-stimuli-induced specific ICD-modifications cause structural substrate changes that enhance ectodomain sensitivity of neuregulin-1 (NRG1; epidermal-growth-factor) or CD44 (receptor-tyrosine-kinase (RTK) co-receptor) to chymotrypsin/trypsin or soluble ADAM. PMID:27876763
5. TGF-beta1-mediated hyaluronan/CD44/STAT3 signaling pathway plays a crucial role in the development of atrial fibrosis and atrial fibrillation. PMID:28871329
6. The role of CD44 was evaluated in CD44(-/-) challenged with a methionine- and choline-deficient diet (MCDD). Liver inflammation, liver injury and fibrosis strongly decreased in CD44(-/-) mice compared to wild-type mice on MCDD. PMID:28323124
7. Data (including data from studies using transgenic mice) suggest that a single oral dose of vitamin A (1) amplifies tolerogenic activity of dendritic cells migrating to lymphoid tissue and (2) up-regulates expression of Foxp3 and Cd44 in co-cultures of dendritic cells and CD4+ lymphocytes. (Foxp3 = forkhead box P3; Cd44 = homing receptor) PMID:28917953
8. The pseudo-hypoxic phenotype of stem-like glioma cells is achieved by stabilization of HIF-2a through interaction with CD44, independently of oxygen. PMID:28813675
9. the survival outcomes of genetically induced glioma-bearing mice and of high-grade human glioma patients are biphasically correlated with CD44 level, with the poorest outcomes occurring at intermediate levels. PMID:28052252
10. pERK1/2 is a regulator of CD44 expression, and increased CD44 expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis. PMID:27998643
11. MET signaling regulates intestinal homeostasis and regeneration, as well as adenoma formation. These activities of MET are promoted by the stem cell CD44 isoform CD44v4-10. PMID:28716720
12. study demonstrates that CD44 plays a critical role in the regulation of experimental autoimmune encephalomyelitis through alterations in the gut microbiome profile and short-chain fatty acid production PMID:28543188
13. CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium. PMID:28497484
14. OA/GPNMB acts through ERK and AKT signaling pathways in mesenchymal stem cells via CD44 PMID:26442636
15. These findings support the usefulness of the conditional Cd44 allele in unraveling essential physiological and pathological functions of CD44 isoforms. PMID:27831556
16. CD44 role in the atrophic epidermis PMID:28099467
17. CD44(high) type II cells likely represent a type II cell subpopulation important for constitutive regulation of alveolar homeostasis. PMID:28473330
18. CD44V6 is part of a positive-feedback loop with TGFbeta1/TGFbetaRI signaling that acts to increase NOX4/ROS production, which is required for myofibroblast differentiation, myofibroblast differentiation, myofibroblast extracellular matrix production, myofibroblast invasion, and myofibroblast contractility. PMID:28389561
19. HAS2-produced hyaluronan is required for CD44V6 and TGFbetaRI co-localization and subsequent CD44V6/ERK1/EGR1 signaling. These results demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGFbeta1-stimulated CD44V6/ERK/EGR1 signaling. PMID:28389562
20. CD44 promotes accumulation of M2 macrophages, extracellular matrix deposition, and wall thickening during arteriovenous fistula maturation. PMID:28450292
21. CD44-expressing Neural Stem Cells are self-renewing and multipotent and they synthesize Hyaluronan that accumulates with aging. CD44-null Neural Stem Cells demonstrate increased proliferation in vitro and in vivo. PMID:28154169
22. CD44 knockout mice are more susceptible to stress-induced anxiety-like behavior than control mice. PMID:27619521
23. CD44 contributes to effective antibacterial defense during S. zooepidemicus infection, thereby limiting the accompanying injury and death. PMID:28062002
24. These studies demonstrate that both endometrial cell and peritoneal mesothelial cell CD44 play a role in the development of early endometriotic lesion. PMID:26169039
25. Targeting CD44 expressing colon cancer cells with anti-CD44 monoclonal antibody improves cellular uptake and antitumor efficacy of liposomal doxorubicin. PMID:26518722
26. depletion of CD44s inhibits breast cancer cell metastasis to the lung in animals. These findings suggest a crucial mechanism underlying the role of the CD44s splice isoform in breast cancer metastasis. PMID:26869223
27. MGK as hydrophobic moieties and oHA as the target of CD44 receptor. PMID:24892632
28. CD44, NOD2, and Fas have distinct functions in regulating changes in trabecular and cortical bone indices during unloading. PMID:26546009
29. The absence of CD44 in neonatal bone marrow has no impact on the size of the long-term reconstituting hematopoietic stem cell pool, but results in an enhanced long-term engraftment potential of hematopoietic stem cells. PMID:26546504
30. CD44 deficiency can reduce osteoclast activity and counteract cortical bone loss in the hindlimb of unloaded mice. PMID:26530337
31. Genetic deficiency of CD44 augments activation, apoptosis and pro-thrombotic potential of platelets. PMID:26355696
32. The high targeting ability of HA-MFNPs was observed at MKN-45 cells (gastric cancer cell line) which high-expressing CD44 in contrast with MKN-28 cells which low-expressing CD44. PMID:27398445
33. the aggravation of pulmonary inflammation upon combined exposure to allergen and an environmental pollutant is CD44-dependent. PMID:26999446
34. CD44 promotes chemoresistance in T-ALL by increased drug efflux. PMID:26708679
35. HA-binding to CD44-expressing beta cells is implicated in beta-cell demise PMID:26624007
36. Peptide inhibitors of CD44v6 isoforms block tumor growth and metastasis in several independent models of pancreatic cancer. PMID:26597578
37. Suggest CD44 is involved in the development of mucous metaplasia in mice infected with Helicobacter pylori. PMID:26639196
38. CD44 enhances T cell receptor signaling strength by delivering lymphocyte-specific protein kinase, which is required for induction of IL-17 producing T helper cells PMID:26172046
39. Endogenous hyaluronic acid increases Lgr5(+) stem cell proliferation, crypt fission, and intestinal lengthening and that these effects are dependent on signaling through CD44 and TLR4. PMID:26505972
40. consistent with CD44's pivotal role in modulating several diverse behaviors important for adhesion, proliferation, apoptosis, migration and invasion during development, growth, repair, maintenance and regression of a wide variety of mesenchymal tissues PMID:26248063
41. The current study reports a unique approach to study H. pylori interaction with the human gastric epithelium. Here, we show that CD44 plays a functional role in H. pylori-induced epithelial cell proliferation. PMID:25658601
42. CD44 and pro-NRG1 are posttranslationally modified at their intracellular domains. PMID:26217011
43. Data indicate that a short course of anti-CD44 treatment improved Treg cell therapy efficacy in type 1 diabetes (T1D) model. PMID:25447401
44. Thymic innate CD8(+)CD44(hi) SP T-cells have critical roles in influenza A(H1N1)pdm09 infection-induced thymic atrophy through secreting IFN-gamma. PMID:25275588
45. CD44 deficiency could result in decreased proinflammatory cytokine production in lung induced by porcine circovirus type 2 (PCV2) in mice, suggesting a previously unrecognized role for CD44 in the development of pneumonia response to PCV2 infection. PMID:25294252
46. PRG4 is a novel putative ligand for CD44 and may control synoviocyte overgrowth in inflammatory arthropathies via a CD44-mediated mechanism. PMID:25708025
47. These data support an important role for CD44 in locomotor and sensorimotor functions, and in spatial memory retention. PMID:25219362
48. This study displays for the first time a different role of CD44-specific isoforms in the progression of chronic kidney disease. PMID:24717295
49. We hypothesize that polyvalent electrostatic interactions are responsible for the assembly of CD44 clusters and the multimeric PIP2-CD44-Ezrin complexes. PMID:25572402
50. of the transcripts of tissue inhibitors of matrix metalloproteinases (TIMPs) showed that expression of both TIMP1 and TIMP2 correlates negatively with the invasive potential of cells. PMID:25180193

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UNIGENE: Mm.423621

KEGG: mmu:12505

STRING: 10090.ENSMUSP00000005218