Recombinant Mouse C-X-C chemokine receptor type 1 (Cxcr1)

1. these studies define CXCR1 as a novel, noncanonical chemokine receptor that regulates pulmonary anti-Pseudomonas host defense with broad implications for cystic fibrosis, chronic obstructive pulmonary disease and other infectious lung diseases PMID:26950764
2. CXCR1 and CXCR2 regulate hepatocyte exosome release. The mechanism utilized by CXCR1 remains elusive, but CXCR2 appears to modulate Nsm activity and resultant production of ceramide to control exosome release. CXCR1 is required for packaging of enzymes into exosomes that mediate their hepatocyte proliferative effect. PMID:27551720
3. These data demonstrate a biological function for mouse Cxcr1 in vivo and indicate that CXCR1-dependent neutrophil effector function is a critical innate protective mechanism of fungal clearance and host survival in systemic candidiasis. PMID:26791948
4. in view of recently-published experimental data obtained in NOD mice, we argue for possible Cxcr1 involvement in type 1 diabetes pathogenesi PMID:26230114
5. expressed 33-110-fold higher in hepatocellular carcinoma polymorphonuclear myeloid-derived suppressor cells PMID:25891236
6. CXCR1 expression is induced in staphylococcus aureus-infected macrophages but not in control macrophages. PMID:25129059
7. Pharmacologic blockade of CXCR1/2 as well as genetic deletion of NAP-2 markedly reduced leukocyte shape change and intrathrombus migration. PMID:23550035
8. Blockade of the CXCL1-CXCR1/2 axis in mice improved intrahepatic islet engraftment. The CXCR1/2-mediated pathway is a regulator of islet damage. PMID:22996693
9. Upon activation by CXCL8, CXCR1 predominantly couples to G protein-coupled receptor kinase (GRK)2 to modulate leukocyte functions. PMID:22869904
10. Xiaotan Sanjie Decoction XTSJD can decrease the protein expressions of IL-8 and its receptors CXCR1/CXCR2 in tumor xenografts and gastric tissue adjacent to the tumor. PMID:20082763
11. data suggest that CXCR1 does not mediate the proliferative effects of ELR+ CXC chemokines during liver regeneration after partial hepatectomy PMID:21693308
12. CXCR1 expression is induced in hepatocytes after injury. Furthermore, the data suggest that CXCR1 has divergent effects from CXCR2 and appears to facilitate repair and regenerative responses after I/R injury. PMID:21254176
13. CX3CL1-CX3CR1 axis can regulate the expression of iNOS, a crucial mediator of DSS-induced colitis. PMID:20335311
14. mCXCR1 may mediate the recruitment of neutrophils to the inflammation site under certain infections PMID:15967374
15. The gene encoding mCXCR1-like was mapped to mouse chromosome 1 and its genomic organization was determined to be very similar to the organization of the gene encoding hCXCR1. PMID:16084593
16. CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8 in mouse PMID:17197447
17. CXCR1 cleavage on neutrophils disables bacterial killing in cystic fibrosis lung disease PMID:18059279
18. Blockade of CXCR1/CXCR2 receptors inhibits neutrophil recruitment by inhibiting the adhesion of neutrophils to synovial microvessels. As a consequence, there is decreased local cytokine production and ameloriation of arthritis in the tissue. PMID:18668539

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UNIGENE: Mm.337035

KEGG: mmu:227288

STRING: 10090.ENSMUSP00000049714