Recombinant Mouse C-C chemokine receptor type 8 (Ccr8)

1. CCR8 negatively regulates migration of cutaneous dendritic cells from the skin to the draining lymph nodes in contact hypersensitivity by keeping these cells in the skin. PMID:25344933
2. Chemokine receptor CCR8 is required for lipopolysaccharide-triggered cytokine production in mouse peritoneal macrophages. PMID:24714157
3. A sustained donor Treg presence is critical for their beneficial properties, and that their survival depends on CCR8 and donor but not host CD11c(+) Aantigen presenting cells. PMID:23798714
4. Expression of CCR-8 in microglia was upregulated in the presence of CCL-1. PMID:23747724
5. C-terminal clipping of chemokine CCL1/I-309 enhances CCR8-mediated intracellular calcium release and anti-apoptotic activity PMID:22479563
6. Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C-C motif chemokine receptor 8 in mice. PMID:22031018
7. a key regulator of Th2 cell skin recruitment during IL-5-mediated allergic inflammation PMID:21217759
8. mediates increased responsiveness of murine eosinophils to TCA-3 PMID:12050188
9. Data from three different models plus an in vivo blocking study clearly show that the Th2 cell-mediated pathological response to ovalbumin-induced allergic airway inflammation is not critically CCR8-dependent. PMID:12574386
10. sulfation at specific positions of the N-terminal domain of mouse CCR8 is critical for its biological activity, whereas glycosylation has a minor influence PMID:14736884
11. IL-10 production correlates with CCR8 ligand (CCL1) expression and the appearance of CCR8+ cells in granulomatous lungs and is required for full expression of the T helper type 2 cell response to parasite antigens. PMID:15699124
12. CCR8 may have a negative impact on host defense during septic peritonitis, providing a new paradigm for the role of CCR8 in innate immunity. PMID:16384913
13. CCR8 ligands are allotropic, binding to distinct sites within CCR8 PMID:17023422
14. CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. PMID:17082609
15. Ccr8 has a pivotal role in the progression of experimental fungal asthma. PMID:17321573
16. Mast cell-derived CCR8- and CCL1-expressing CD4-positive effector T lymphocytes play an essential role in orchestrating lung mucosal inflammatory responses. PMID:17641040
17. Results suggest that CCR8 plays a significant role in the pathogenesis of experimental autoimmune encephalomyelitis and probalby of multiple sclerosis. PMID:17850582
18. CCR8/CCL1 interaction may play a role in type 1 diabetes through macrophage recruitment and activation PMID:17947648

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UNIGENE: Mm.442098

KEGG: mmu:12776

STRING: 10090.ENSMUSP00000038473