Recombinant Mouse Bone morphogenetic protein receptor type-1B (Bmpr1b)

1. Study concludes that growth/differentiation factor-5 (GDF-5) protects hippocampal neurons against kainic acid-induced neurodegeneration by signaling through bone morphogenetic protein receptor type IB, suggesting a therapeutic potential for GDF-5 in neurodegenerative diseases. PMID:28458020
2. dermal BMPRIB+ cells possessed a similar osteogenic differentiation potential with BMSCs in a mouse model. Dermal BMPRIB+ subpopulations possessed low immunogenicity and immunosuppressive properties before and after osteogenic differentiation. PMID:27552226
3. BMPR1B plays distinct roles from BMPR1A and ACVR1 in maintaining bone mass and transducing BMP signaling PMID:27048979
4. Local administration of adenovirus expressing siRNA-targeting BMPR-IB may be a feasible and effective therapeutic candidate to treat or prevent wear debris-associated osteolysis. PMID:22827452
5. Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity PMID:23250207
6. the BMP-2-BMPR-IB-ODAM-MAPK signaling cascade has important roles in ameloblast differentiation and enamel mineralization PMID:22213140
7. Variation in BMPR1B is associated with dizygotic twinning. PMID:21962132
8. results indicate a requirement for BMP signaling in generating the dorsalmost neuronal lineage of the telencephalon, DG granule neurons, and in the development of the stem cell niche that makes neurons in the adult hippocampus. PMID:20445055
9. TbetaRIII enhanced ALK6-mediated stimulation of the BMP-responsive promoters XVent2 & 3GC2, & up-regulation of the early-response gene Smad6. Interaction with ALK6 required both the extracellular & cytoplasmic domains. PMID:19726563
10. effects of loss of one of the BMP receptors, the BmprIb, on the development of the eye by using targeted deletion PMID:12654290
11. signaling through bone morphogenetic protein (BMP) type 1 receptors is required for the formation of two populations of commissural neurons, DI1 and DI2 PMID:15469980
12. Data demonstrate that the osteogenic commitment of multipotent mouse adipose-derived adult stromal cells requires retinoic acid, which enhances expression of the critical bone morphogenetic protein receptor-IB isoform. PMID:16894153
13. HGF up-regulates the expression of the bone morphogenetic protein receptors, BMPR-IB and BMPR-II, in prostate cancer cells PMID:17203235
14. the combination of constitutively active activin receptor-like kinase 6 (caALK6) and Runx2 efficiently induced osteogenic differentiation in various cell types, including terminally differentiated nonosteogenic cells PMID:17317722
15. Expression of BMP receptors Ib and II, and Smads 4, 5, 6, and 8, was downregulated in lungs but not kidneys of MCT-treated rats. PMID:17347486
16. BMPRs-Ib, -II, the activin receptor-1 (ActR-1) and the phosphorylated Smad1 were detected in DF and HERS at D6 and later more diffusely in the periodontium. BMPR-Ia detection was restricted to alveolar bone. PMID:17662325
17. crystals consisted of the full ternary complex GDF5-BRIB-ActRIIB, but only diffracted to low resolution PMID:19652338

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UNIGENE: Mm.39089

KEGG: mmu:12167

STRING: 10090.ENSMUSP00000029948