Recombinant Mouse 5,6-dihydroxyindole-2-carboxylic acid oxidase (Tyrp1)

1. Genetic modulators of IOP thus may be independently identified using the full array of BXD mice without concern for the presence of transillumination defect or mutations in Typr1 and/or Gpnmb. PMID:27011731
2. the results from the present study demonstrate that the MA extract increases melanogenesis through the upregulation of TRP-1 protein expression by post-transcriptional control in B16F10 cells PMID:25872655
3. Addition of a TRP-1-directed monoclonal antibody to the treatment protocol for B16F10 skin melanoma mediates eradication of subcutaneous lesions. PMID:23203930
4. analysis of tyrosinase-related protein 1 in mouse melanocytes at early embryonic stage PMID:22705010
5. GILT-deficient mice have an increase in TRP1-specific regulatory T (Treg) cells compared with TRP1-deficient mice, and depletion of Treg cells partially restores the ability of GILT-deficient TRP1-specific CD4(+) T cells to induce vitiligo. PMID:21833020
6. The Tyrp1b mutation modifies the pathways and gene networks in which Tyrp1 functions. PMID:21976956
7. DNA vaccination with a melanoma-shared antigen Trp1, combined with systemic TGF-beta blockade during the perioperative period of primary tumor resection, confers protection against B16 melanoma. PMID:21289306
8. both the Rab32/38 binding activity and VAMP7 binding activity of Varp are essential for trafficking of Tyrp1 in melanocytes but activation of Rab21 by the VPS9 domain is not necessary for Tyrp1 trafficking PMID:21187289
9. Tyrosinase-related protein 1 (Tyrp1) displayed enriched expression in the dorsal root ganglia, an inactivating mutation in the A/J mouse strain, and a null mutant found to be more resistant to thermal nociception compared to its wild-type counterpart. PMID:20633051
10. this study suggests that DHICA monomers are required to incorporate into the DHI polymer backbone of eumelanin, which highlights the important role of Dct in the regulation of DHICA-mediated antioxidation. PMID:20123016
11. We found that ionophore monensin (Mon) and the quaternary amine chloroquine (CQ) discriminate between the traffic routes of TRP-2 and TRP-1 PMID:15707965
12. used sequence polymorphisms to finely map the deletion breakpoints and identify strong candidate genes for the known phenotypes PMID:16505357
13. The presence of a distal Tyrp1 regulatory element, which specifies melanocyte-specific expression, supports the idea that separate regulatory sequences can mediate differential gene expression in melanocytes and RPE. PMID:16934245
14. the role of Tyrp1 mechanisms involved in the subsequent IOP elevation and optic nerve degeneration remain unclear PMID:17608931
15. NZG/Kgm mouse has two recessive pigmentation variant genes (oca2(p) and tyrp-1(b)) and that the tyrp-1(b) gene locus associates with large body size. PMID:19293329
16. Varp functions as the Rab32/38 effector that controls trafficking of Tyrp1 in melanocytes. PMID:19403694
17. Data demonstrate that endogenous tyrosinase-related protein-1 expression alters the functionality of the autoreactive T cell repertoire. PMID:19561540

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UNIGENE: Mm.30438

KEGG: mmu:22178

STRING: 10090.ENSMUSP00000006151