Recombinant Mouse 5-hydroxytryptamine receptor 4 (Htr4)

1. Prefrontal cortex 5-HT4Rs mediate hypophagia following stress. PMID:29069597
2. Study shows that in the murine gastrointestinal tract, activation of 5-HT4 receptors with prucalopride enhances cholinergic contractions, illustrating facilitation of myenteric cholinergic neurotransmission. PMID:28332745
3. These data suggest that correlated expression of Slc6a4 and Htr4 likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut. PMID:27072889
4. altered 5-HT4R expression may affect the development of cortical glutamatergic control of the dorsal raphe nucleus. PMID:28108396
5. Results demonstrate that the absence of 5-HT4 receptors triggers adaptive changes that could maintain emotional states, and that the behavioural and molecular effects of fluoxetine under pathological depression appear to be critically dependent on 5-HT4 receptors. PMID:27586007
6. HTR4's role in pulmonary function likely relates to neural innervation and control of breathing. PMID:28130264
7. 5-HT4 receptor regulating insulin secretion and acting as a potential drug target in diabetes treatment PMID:27423314
8. Its activation facilitates neurogenesis of injured enteric neurons.(review) PMID:26658112
9. The findings of altered lung function and increased AHR in Htr4-null mice support a causal relationship between genetic variation in HTR4 and pulmonary function identified in human genome-wide association studies. PMID:25342126
10. Our in vivo data using pharmacologic and genetic approaches suggest that 5-HT(4) receptors are not involved in the bronchial hyperresponsiveness to 5-HT in cigarette smoke-exposed mice PMID:24183679
11. A highly conserved motif in the ligand-binding pocket of serotonin receptors is an important participant in ligand binding. PMID:23378516
12. These results suggest a prominent role of 5-HT(4)R in promoting angiogenesis. PMID:22903372
13. Endogenous 5-HT exerts a dual role in the pathogenesis of indomethacin-induced intestinal lesions: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors. PMID:22699012
14. This review presented that the 5HT4 RECEPTOR knockout mice show a correlation between 5-HT firing rate and depressive/resilience phenotypes. PMID:23089640
15. These results show that prenatal stress and reduced 5-HT levels can alter 5-HT(4)R expression in the developing forebrain and that some 5-HT(4)R splice variants. PMID:22564922
16. This study demonistrated that alternatively spliced multiple transcripts of 5-hydroxytryptamine receptor expression in heart. PMID:22079627
17. Mucosal 5-HT(4) receptor activation can mediate the prokinetic and antinociceptive actions of 5-HT(4)R agonists. PMID:22226658
18. G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient. PMID:21247891
19. -HT-R splice variants and beta-ARs are differentially regulated in the embryonic telencephalon PMID:20805681
20. adaptive changes in cholinergic systems may circumvent the absence of 5-HTR(4) to maintain long-term memory under baseline conditions PMID:20209108
21. After bulbectomy, 5-HT(4) receptor binding was increased in the ventral hippocampus but unchanged in the dorsal hippocampus, frontal and caudal caudate putamen PMID:20060867
22. These results suggest that during development 5-HT4-R expression undergoes a dynamic regulation and that this regulation may be important for the normal development of sensory and limbic processing. PMID:19998416
23. 5-HT4 receptor knock-out mice have an attenuated response to stress and increased susceptibility to seizures. PMID:14724239
24. The mechanisms underlying feeding disorders in 5-HT4 receptor knockout mice are related to a lesser efficacy of 5-HT (hypothalamus, nucleus accumbens), leptin and the cocaine-amphetamine related transcript to reduce food intake following stress. PMID:15146954
25. SNX27 and NHERF specifically interact with the 5-HT4a receptor splice variant PMID:15466885
26. the uncoupling and endocytosis of 5-HT4R require different GRK2 concentrations and involve distinct molecular events PMID:15919661
27. 5-HT(4a), 5-HT(4b), 5-HT(4e), and 5-HT(4f) isoforms were found in mouse brain and gut. Enteric neuronal 5-HT(4) receptors thus are presynaptic and probably exert their prokinetic effects by strengthening excitatory neurotransmission. PMID:16037544
28. Results describe the adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse. PMID:16930432
29. These and previous data collectively suggest that the 5-HT4 receptor may be an effective therapeutic target for AD, providing both symptomatic improvements and neuroprotection. PMID:16978609
30. Activation of colonic myenteric neurons in the 5-HT4 receptor-mediated colonic propulsive motor response. PMID:16990446
31. Data show that 5-HT(4) receptor stimulation in primary neurons produced a potent but transient activation of the ERK pathway that is dependent on Src tyrosine kinase but totally independent of beta-arrestin. PMID:17377064
32. Serotoninergic 5-HT4 receptor plays an important role in mouse fetal development; in BALB/c mice there is a direct relation between its expression and the deleterious effect of maternal anti-5-HT4 receptor autoantibodies in early embryogenesis. PMID:17445258
33. These findings provide evidence that 5-HT(4)Rs stimulation selectively increases experience-dependent structural plasticity in learning-activated hippocampal circuits. PMID:18075492
34. Essential role of p11 in modulating signaling through 5-HT4 as well as 5-HT1B receptors supports the concept of p11 protein as a key determinant of vulnerability to depression. PMID:19211900
35. This is the first demonstration of adult enteric neurogenesis; our results suggest that 5-HT(4) receptors are required postnatally for enteric nervous system growth and maintenance. PMID:19657021

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UNIGENE: Mm.20440

KEGG: mmu:15562

STRING: 10090.ENSMUSP00000027560