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Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 5 (CCR5)

Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 5 (CCR5)

CSB-CF004844MOW

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20μg100μg

US$5128

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Express system: in vitro E.coli expression system

Species: Macaca mulatta (Rhesus macaque)

Tag Info: N-terminal 10xHis-tagged

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Target Background

Product Details

Target Names

CCR5

Uniprot NO.

P61813

Species

Macaca mulatta (Rhesus macaque)

Source

in vitro E.coli expression system

Expression Region

1-352

Target Protein Sequence

MDYQVSSPTYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKR LKSMTDIYLLNLAISDLLFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII LLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSS HFPYSQYQFWKNFQTLKMVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL

Protein Length

Full length protein

Tag Info

N-terminal 10xHis-tagged

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Target Background

Function

Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor.

Gene References into Functions

CCR5 inhibition may provide a cardioprotective benefit in SIV infection by preventing cardiomyocyte CCR5 signaling. PMID:24695652
A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251. PMID:24307581
CCR5 downregulation on CD4(+) T cells by TCR activation has no measurable effect on susceptibility to SAIDS. PMID:21035160
CD4 and CD8 T cells are more vulnerable to SIV infection, indicating the the ability to express CCR5 may activate and hassten T cell death by SIV infection in vitro. PMID:20224239
Results estimate the infectivity of CCR5-tropic simian immunodeficiency virus SIV(mac251) in the gut. PMID:17507462
observed a significantly higher loss of CCR5(+) CD45RA(-) CD4(+) T cells in CD8(+) lymphocyte-depleted macaques than in controls PMID:18367534