Recombinant Human Voltage-gated hydrogen channel 1 (HVCN1)

1. The authors now report that R1H mutation is sufficient to reconstitute resting-state H(+) 'shuttle' conductance in Hv1 without abrogating the intrinsic 'aqueous' H(+) conductance. PMID:27572256
2. We suggest that cleavage and heterodimerization of Hv1 represents an adaptation to the specific requirements of pH control in sperm. PMID:27859356
3. Inhibition of Hv1 channels by Zn(2+). PMID:28013412
4. CREBBP mutations were associated with inferior progression-free survival (PFS), whereas mutations in previously unreported HVCN1, a voltage-gated proton channel-encoding gene and B-cell receptor signaling modulator, were associated with improved PFS. PMID:28064239
5. Trp207 is crucial for slow channel opening, highly temperature-dependent gating kinetics, proton selectivity, and DeltapH-dependent gating. PMID:26458876
6. Our data demonstrated that the expression of Hv1 in pancreatic islet beta-cells regulates insulin secretion through regulating Ca(2+) homeostasis. PMID:26559003
7. The main properties of the voltage-gated proton channel (HV1) are described in this review, along with what is known about how the channel protein structure accomplishes its functions. [review] PMID:25964989
8. Hv1 activity displays hysteresis PMID:25296308
9. A shorter isoform of HVCN1 with enhanced gating is specifically enriched in malignant B cells. PMID:25425665
10. Divalent metal binding causes a conformational change in human the Hv1 c-terminal domain. PMID:24867409
11. analysis of of the C-terminal domain of voltage-gated proton channel HV1 and the thermodynamic characteristics of Zn(2) binding to this domain PMID:25446125
12. Salt bridge networks and the hydrophobic plug function as the gate in Hv1 channels; outward movement of the fourth transmembrane segment leads to the opening of this gate. PMID:24379371
13. Results suggest that Hv1 may be used as a potential biomarker for diagnosis and prognosis of colorectal carcinoma, and a potential target for anticancer drugs in colorectal cancer therapy. PMID:23940591
14. inhibition of Hv1 activity via Zn(2+) ions can effectively retard the cancer growth and suppress the cancer metastasis by the decrease of proton extrusion and the down-regulation of gelatinase activity PMID:23891691
15. In the Hv1 voltage-gated channel a highly conserved phenylalanine is found in the charge transfer center. PMID:23352164
16. Two conformational changes are detected in Hv1 channels that are involved in channel opening. PMID:23352165
17. inhibition of Hv1 function via knockdown of Hv1 expression can effectively retard cancer growth PMID:22367212
18. Hv1 channels maintain a physiological membrane potential during the respiratory burst of neutrophils by providing a compensating charge for the electrons transferred by NOX2 from NADPH to superoxide. PMID:22056415
19. Hv1-dependent reactive oxygen species production is responsible for a substantial fraction of brain damage at early time points after ischemic stroke. PMID:22388960
20. Interactions with two of the S4 arginines and the formation of a well defined hydrophobic gap in the center of the Hv1 are key to the formation of a robust water wire. PMID:21843503
21. identification of aspartate 112 as a crucial component of the selectivity filter of H(V)1 PMID:22020278
22. these results strongly suggest that Hv1 regulates breast cancer intracellular pH and exacerbates the migratory ability of metastatic cells. PMID:21821008
23. Data demonstrated that a massive reduction in H(v)1 expression can limit the Nox2 mediated superoxide production of PLB-985 granulocytes. PMID:21124855
24. The HVCN1 H(+) channel mediates pH-regulated acid secretion by the airway epithelium. Apical HVCN1 represents a mechanism to acidify an alkaline airway surface liquid. PMID:20548053
25. Report on the interaction of HV1 proton channel protomers during ion channel gating. PMID:20676047
26. HVCN1 not only modulates signaling from the B-cell receptor following B-cell activation and histamine release from basophils, but also mediates pH-dependent activation of spermatozoa, as well as acid secretion by tracheal epithelium. [Review] PMID:20961760
27. Molecular dynamics simulations revealed water molecules in the central crevice of Hv1 model structures but not in homologous voltage-sensor domain (VSD) structures. PMID:20543828
28. In the 2.0 A structure of the C-terminal domain, the two monomers form a dimer via a parallel alpha-helical coiled-coil, in which one chloride ion binds with the Neta atom of Arg(264). PMID:20147290
29. Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes PMID:20037153
30. Since Hv1 specifically mediates proton efflux, it is likely to be the long-sought molecule that controls male fertility by mediating intracellular alkalinization of human sperm PMID:20144758
31. Hv1 channels truncated just downstream of R2 in the S4 segment retain most channel properties. PMID:20018719
32. data presented here identify H(v)1 as a long-sought voltage-gated H+ channel and establish H(v)1 as the founding member of a family of mammalian VSD proteins PMID:16554753
33. We cloned a new B cell-specific tetraspanning (BTS) membrane molecule PMID:17948262
34. Hv1 forms a dimer in the membrane;its regions that are close to the dimer interface were defined. PMID:18509058
35. The Hv1 channel voltage sensor domain by itself supports H(+) flux. PMID:19233200
36. The C-terminal domain of the human voltage-gated proton channel Hv1 (C-Hv1) was overexpressed in Escherichia coli, purified and crystallized using the hanging-drop vapour-diffusion method. PMID:19255483

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HGNC: 28240

UNIGENE: Hs.211511

KEGG: hsa:84329

STRING: 9606.ENSP00000242607

OMIM: 611227