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Buffer
Lyophilized from PBS, 6% Trehalose, pH 7.4.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80°C. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.; (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, may recognize and internalize the complex formed by AVP/Arg-vasopressin, SARS-CoV-2 spike protein and secreted ACE2 through DNM2/dynamin 2-dependent endocytosis.
Gene References into Functions
Patients were different from those previously studied. We measured the expression of the pituitary-specific hormone genes and type 1 corticotrophin-releasing hormone and arginine vasopressin 1b receptors, by quantitative real-time polymerase chain reaction using TaqMan probes.PMID:29979686
Polymorphisms of CRHR1 and AVPR1b may modify susceptibility to mood disorders.PMID:23962971
The results suggest that the AVPR1B gene rs28373064 is linked to emotional empathy and prosociality.PMID:26354157
AA genotype of rs28418396 single-nucleotide polymorphism near the arginine vasopressin receptor 1b gene is associated with serious adverse events in patients with septic shock treated with vasopressin and norepinephrine.PMID:24919159
Genetic variance of arginine vasopressin receptor 1B(AVPR1B) contributes to overweight and data indicate a link between AVPR1B variance and diabetes mellitus developmentPMID:26503846
The association of AVPR1B G*A-haplotype (rs28632197 and rs33911258, respectively) and decreased Self-transcendence (TCI-125) was demonstrated in the total sample and in Udmurts.PMID:25438555
Participants carrying both GG/GA variant of AVPR1b rs28373064 and AA variant of clock rs6832769 showed highest scores on the Emotional prosocial tendency measure. the clock gene and OXT/AVP systems are intertwined and contribute to human prosociality.PMID:25309987
The associations of the AVP 1B receptor may be specific to reactive, emotional rather than proactive or callous types of aggression.PMID:24842238
association between polymorphisms of AVPR1b gene and psychotic dimension.possible involvement of the AVPR1b gene in the etiology of psychotic features in the course of affective disordersPMID:24012103
AVPR1B genetic variation has a role in suicide attempt etiology characterized by elevated depression levels.PMID:23422793
The results of thi study showed that no association was found for alleles, genotypes, or haplotype analysis for AVPR1b genes and melancholic depression.PMID:23068076
This is the first report of a genetic association between vasopressin receptor 1B and child aggression.PMID:22910476
polymorphism rs28536160 genotype TT of the AVPR1b gene may increase susceptibility for obtaining psychotic features in the course of bipolar disorder I.PMID:22341483
the presence of V1b receptors also found in human Langerhans islets could suggest hormonal control of AVP in human pancreas.PMID:12736162
Data supports a protective effect of this major haplotype for recurrent major depression.PMID:15094789
determination of a C-terminal motif required for export to plasma membranePMID:15528211
V1bR and CRHR1 can form constitutive homo- and heterodimers.PMID:17318384
study found evidence to implicate the AVPR1B gene in the etiology of mood disorders, particularly in femalesPMID:17909131
polymorphisms in the AVPR1B and the CRHR1 genes alter the susceptibility to panic disorderPMID:18384079
AVPR1B is associated with autistic traits, empathy, and Asperger syndrome.PMID:19598235
An association analysis with AVPR1b single-nucleotide polymorphism for attention deficit hyperactivity disorder, was performed in a patient/control sample.PMID:19668115