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Recombinant Human Transmembrane protein PVRIG (PVRIG)

Recombinant Human Transmembrane protein PVRIG (PVRIG)

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Code: CSB-CF721905HU

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US$1620

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Express system: in vitro E.coli expression system

Species: Homo sapiens (Human)

Tag Info: N-terminal 6xHis-SUMO-tagged

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Target Background

Product Details

Purity

Greater than 85% as determined by SDS-PAGE.

Target Names

PVRIG

Uniprot NO.

Q6DKI7

Research Area

Cell Biology

Species

Homo sapiens (Human)

Source

in vitro E.coli expression system

Expression Region

1-326aa

Target Protein Sequence

MRTEAQVPALQPPEPGLEGAMGHRTLVLPWVLLTLCVTAGTPEVWVQVRMEATELSSFTIRCGFLGSGSISLVTVSWGGPNGAGGTTLAVLHPERGIRQWAPARQARWETQSSISLILEGSGASSPCANTTFCCKFASFPEGSWEACGSLPPSSDPGLSAPPTPAPILRADLAGILGVSGVLLFGCVYLLHLLRRHKHRPAPRLQPSRTSPQAPRARAWAPSQASQAALHVPYATINTSCRPATLDTAHPHGGPSWWASLPTHAAHRPQGPAAWASTPIPARGSFVSVENGLYAQAGERPPHTGPGLTLFPDPRGPRAMEGPLGVR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

50.3 kDa

Protein Length

Full Length

Tag Info

N-terminal 6xHis-SUMO-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Datasheet & COA

Please contact us to get it.

Images

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Description

Explore the potential of the Recombinant Human PVRIG protein, an invaluable resource for advancing your cell biology research. PVRIG, also referred to as the CD112 receptor or Poliovirus receptor-related immunoglobulin domain-containing protein, plays a critical role in diverse cellular processes. Our product is synthesized using an advanced in vitro E.coli expression system, ensuring consistent and reliable production of the protein.

This exceptional product encompasses the full length of the PVRIG protein, spanning amino acids 1 to 326. It features an N-terminal 6xHis-SUMO tag, facilitating easy detection and purification, streamlining your experimental workflows. With a purity level exceeding 85% as determined by SDS-PAGE, you can rely on its exceptional quality to deliver consistent and reproducible results in your research.

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Target Background

Function(From Uniprot)

Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.

Gene References into Functions

Blockade of TIGIT or CD112R, separately or together, enhances trastuzumab-triggered antitumor response by human NK cells. PMID:28623459
Describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor-mediated signals. PMID:26755705

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Tissue Specificity

Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-

Database Links

HGNC: 32190

UNIGENE: Hs.729356

KEGG: hsa:79037

STRING: 9606.ENSP00000316675

OMIM: 617012

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