Recombinant Human TYRO protein tyrosine kinase-binding protein (TYROBP)

1. Heterozygous carriership of the TYROBP deletion is not a major risk factor of cognitive impairment. PMID:29336840
2. Mutations in TYROBP are not a common cause of dementia in this Turkish cohort. PMID:28716534
3. Rare TYROBP variants might contribute to early-onset Alzheimer's disease risk by reduction of TREM2 expression, a well-established risk factor for AD. PMID:27658901
4. TYROBP influences a batch of genes that are related to Alzheimer's disease; ZNF329 and RB1 significantly regulate those 'mesenchymal' gene expression signature genes for brain tumors. By merely leveraging gene expression data, Context Based Dependency Network (CBDN) can efficiently infer the existence of gene-gene interactions as well as their regulatory directions. PMID:27556418
5. TYROBP/CSTA gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis PMID:26676054
6. The different expression of DAP12 compared to TREM2 represents the first description of such variable expressivity in Nasu-Hakola disease (NHD) microglia. PMID:26001891
7. the microglial membrane adaptor protein DAP12 was required for both nerve injury- and intrathecal CSF1-induced upregulation of pain-related microglial genes and the ensuing pain, but not for microglial proliferation PMID:26642091
8. Impaired signaling by the TREM2-DAP12 pathway leads to altered immune responses in phagocytosis, cytokine production, and microglial proliferation and survival, thus contributing to disease pathogenesis. Review. PMID:26337043
9. T cells modified to express a KIR-CAR and DAP12 exhibit superior antitumor activity compared with standard first- and second-generation CD3zeta-based CARs in a xenograft model of mesothelioma highly resistant to immunotherapy. PMID:25941351
10. This study reveled that TYROBP having a central role in the bipolar disease and schizophrenia manifestation. PMID:25487697
11. isolated PMNs have an increased proportion of both TREM1 and DAP12 compared to normal healthy control PMID:25642940
12. results support a role of DAP12 in stabilizing TREM2-CTF, thereby protecting against excessive pro-inflammatory responses. PMID:25957402
13. Its mutation is a known genetic cause of Nasu-Hakola disease. PMID:24612676
14. Data indicate that NKG2 receptor NKG2E was capable of associating with CD94 and DAP12 but that the complex was retained intracellularly at the endoplasmic reticulum. PMID:24935923
15. Macrophage traits in BRC cells facilitate the metastatic process and DAP12 expression might promote metastatic homing to bone and liver tissues. PMID:23810293
16. DAP12 has a role in trafficking newly synthesized KIR to the cell surface. It interacts with an immature KIR2DS isoform likely initiating in the ER. DAP12also impacts KIR2DS surface stability. PMID:23715743
17. dynamics and dimerization of the TM helix of DAP12 in the membrane bilayer PMID:23561520
18. A molecular defect of DAP12 in human monocytes deregulates the gene network pivotal for maintenance of myeloid cell function in Nasu-Hakola disease. PMID:22080356
19. the putative periodontal pathogen P. gingivalis can positively regulate the expression of the TREM-1/DAP12 pathway in monocytic cells. PMID:21967868
20. DAP12 gene levels were not increased in the monocytes of schizophrenic, bioplar or major depressive disorder patients. PMID:21421043
21. Data suggest that OSCAR is a collagen receptor that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12-deficient humans and mice. PMID:21841309
22. A transgenic mouse model demonstrates that induction of tolerance in Ly49H-positive natural killer (NK) cells by chronic exposure to virus-encoded ligand m157 requires signaling through the Ly49H adaptor protein DAP12, not the DAP10 adaptor protein. PMID:21263069
23. Meta-analysis of gene-disease association. (HuGE Navigator) PMID:20628624
24. These findings indicate that DAP12, possibly through association with TREM2, contributes to alveolar macrophage chemotaxis and recruitment to the lung and may mediate macrophage accumulation in lung diseases such as emphysema. PMID:20421649
25. DAP12-associating lectin (MDL)-1 receptor is a key regulator of synovial injury and bone erosion in autoimmune joint inflammation. PMID:20212065
26. Mutations in two genes encoding different subunits of a receptor signaling complex (TYROBP and TREM2) result in an identical disease phenotype PMID:12080485
27. Myeloid abnormalities seen in KARAP/DAP12-transgenic mice indicate that KARAP/DAP12-driven signals are involved in inflammation & constitute an essential target to control resolution of inflammatory disorders based on monocytes/macrophages & neutrophils. PMID:12207350
28. DAP12 has a role in signal transduction, bone modeling, and brain myelination [review] PMID:12569153
29. CD158j in T cells functions as a costimulatory molecule through the JNK pathway independent of KARAP/DAP12 and DAP10. PMID:12591902
30. These results indicate an important role for DAP12-TREM2 signaling complex in the differentiation and function of osteoclasts. PMID:12925681
31. DAP12 association with natural cytotoxicity receptor NKp44 is required for activating properties and surface expression of NKp44 in natural killer (NK) cells. PMID:14707061
32. In clones that lack expression of KARAP/DAP12, stimulation of killer Ig-receptor KIR2DS2 does not induce cytotoxicity, whereas expression of KARAP/DAP12 is sufficient to convert a costimulatory KIR receptor into a stimulatory molecule. PMID:15356118
33. Splenic mature dendritic cells from transgenic mice with DAP12 overexpression are characterized by an impaired tolerogenic potential PMID:16206234
34. requirement by activated and expanded CD8+ T cells for DAP12 for direct killing PMID:16339517
35. Nasu-Hakola disease due to a DAP12 mutation 4. PMID:16505336
36. This review discusses the dual functionality of DAP12 and presents evidence that DAP12 can suppress as well as activate natural killer (NK) cells. PMID:17100880
37. This is the first case of Nasu-Hakola disease caused by compound heterozygosity for loss-of-function mutations in DAP12. PMID:17125796
38. KIR3DS1 associates with the ITAM-bearing adaptor, DAP12 PMID:17202323
39. activation signals delivered via DAP12 can be counterbalanced by the adaptor NTAL PMID:17277102
40. Transcript analysis of DCs of PLOSL patients show that DAP12 deficient cells differentiated into DCs and responded to pathogenic stimuli. However, the DCs showed morphological differences due to defects in the actin filaments. PMID:17530208
41. the DAP12-TREM2 complex unlikely has a role in genetic susceptibility of multiple sclerosis PMID:19019460
42. Downstream targets of DAP10 and DAP12 are constitutively activated in large granular lymphocyte leukemia cells, and expression of dominant-negative DAP10 and DAP12 dramatically reduces their lytic capacity. PMID:19075187
43. loss of function mutation results in recessive genetic disorder, Nasu-Hakola disease (bone development abnormalities and dementia at adolescence) PMID:19120482
44. describe the generation and the characterization of an anti-DAP12 monoclonal antibody. Using this novel reagent, we show that DAP12 expression is restricted to innate immune cells in basal condition PMID:19606219

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HGNC: 12449

UNIGENE: Hs.515369

KEGG: hsa:7305

STRING: 9606.ENSP00000262629

OMIM: 221770