Recombinant Human Receptor activity-modifying protein 1 (RAMP1)

1. T-A-T RAMP1 gene haplotype might have utility as a genetic marker for Essential Hypertension and that the RAMP1 gene may be associated with increased susceptibility to Essential Hypertension in a Japanese population. PMID:28181496
2. Evidence that DNA methylation at RAMP1 gene promoter plays a role in migraine was described. PMID:26501962
3. RAMP1 rs7590387 has a role in the transformation of episodic migraine into medication overuse headache. PMID:25881990
4. A novel functional role for RAMP1 in regulation of CaSR signalling in addition to its known role in receptor trafficking, is reported. PMID:24454825
5. multiple NKX3.1 binding sites were found in the RAMP1 locus in human prostate cancer cells and in the normal mouse prostate. PMID:23867798
6. RAMP1 overexpression enhances the promoting effect that exogenous CGRP has on osteogenic differentiation PMID:22949393
7. No significant association of the tested SNPs of the RAMP1 gene were found with migraine susceptibility. PMID:23237777
8. CLR and RAMP1 co-localize in the enteric nervous system of human stomach, ileum, and colon, and are in close proximity to their ligands CGRP and IMD PMID:22484227
9. The present finding demonstrated that RAMP1 immunoreactivity was localized in many neurons and phenopalatine ganglion. PMID:22208649
10. lower expression in bronchial biopsies from subjects with asthma PMID:20933260
11. The T-A-C haplotype is a genetic marker for cerebral infarction, and RAMP1 is associated with increased susceptibility to cerebral infarction. PMID:19710695
12. These data for the first time pinpoint a specific RAMP1 residue important for both antagonist and agonist potency and are consistent with the N-terminal domain of RAMP1 forming the binding pocket interface with calcitonin receptor-like receptor. PMID:20188075
13. RAMP1 overexpression attenuates Ang-II-induced hypertension and induces a protective change in cardiovascular autonomic regulation PMID:20100989
14. Co-expression of RAMP1 and CRLR reconstituted a CGRP receptor that was able to activate the pheromone-signaling pathway with pharmacological properties similar to those observed previously in mammalian cells. PMID:11733510
15. Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists. PMID:11847213
16. The extracellular domain of receptor activity-modifying protein 1 is sufficient for calcitonin receptor-like receptor function PMID:12574158
17. identification of domains responsible for agonist binding specificity PMID:12684503
18. TNF-alpha induced time- and dose-dependent decreases in the expression of RAMP1 mRNA in cultured human coronary artery smooth muscle cells, thereby diminishing AM-evoked cAMP production PMID:15245870
19. calcitonin receptor-like receptor heterodimer with RAMP1 yields a calcitonin gene-related peptide receptor PMID:15613468
20. RAMP1 interacts with tubulin. PMID:17493758
21. Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor and RAMP1. PMID:17785463
22. We did not observe any difference in mRNA for CL-R and RAMPs in arteries from patients with hemorrhagic stroke, arteriosclerosis and acute myocardial infarction when compared to patients without these diagnoses PMID:18198792
23. RAMP1 may be strongly considered as a candidate gene for migraine. PMID:18240900
24. Identification of RAMP1 residues important for calcitonin gene-related peptide are reported. PMID:18593822
25. the crystal structure of the extracellular domain of human RAMP1 at 2.4 A resolution was determined. PMID:18725456

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HGNC: 9843

UNIGENE: Hs.471783

KEGG: hsa:10267

STRING: 9606.ENSP00000254661

OMIM: 605153