Recombinant Human Proteinase-activated receptor 3 (F2RL2)

1. PAR3 is essential in thrombin stimulated insulin secretion. PMID:26742564
2. TFRGAP, a PAR-3 mimicking peptide significantly induced the phosphorylation of eNOS-Thr-495 with minimal phosphorylation of eNOS-Ser-1177 with no change in nitric oxide production. PMID:26729042
3. These data provide intriguing novel insights into the diversification of functional selectivity of protease signaling achievable by canonical and noncanonical PAR activation, such as the activation of vascular-protective Tie2 by noncanonical PAR3 activation. PMID:25320242
4. In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin, leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav. PMID:24699825
5. Elevated expression of PAR-3, but not PAR-4, was detected in the lungs of idiopathic pulmonary fibrosis patients. PMID:23739922
6. A unique contributory role for PAR3 in the complex mechanisms underlying Activated protein C cytoprotective effects. PMID:23788139
7. PAR-3 receptors interact with thrombin and increase heme oxygenase-1 expression in synovial fibroblasts. PMID:22541814
8. Human PAR-3 is regulated post-transcriptionally via the mRNA-stabilizing factor HuR, whereas transcriptional control involves nuclear factor of activated T cells (NFAT). PMID:21596928
9. FXa bound in a punctate manner to thrombi under shear, while thrombin and fibrin(ogen) distributed ubiquitously over platelet-fibrin thrombi PMID:20454680
10. genetic polymorphism is associated with peripheral arterial disease severity PMID:20390230
11. A novel role is identified for PAR3 in thrombin signaling. PMID:20442298
12. Down-regulation of connexin and par-3 signals early anaplasia and malignant change in rectal cancer. PMID:19513616
13. upregulated thrombin generation and inhibition of fibrinolysis, occurred in one-third of the Stem cell transplant patients associating with the development of Graft versus host disease PMID:19718071
14. Lower plasma levels of thrombin-antithrombin complex correlate to higher recanalisation rates after ischaemic stroke PMID:19806263
15. PAR-3 is expressed in human SMC and triggers intracellular calcium signaling. PMID:14515192
16. expression of PAR3 mRNA and protein in cells undergoing megakaryocytic maturation suggests a developmental role for PAR3; regulation of PAR3 expression appears to be specifically coupled to the protein kinase C system. PMID:15504554
17. a Na-independent Cl-/HCO3- exchange mechanism mediates the recovery of pHi from alkalosis in platelets and that thrombin activates this exchanger by a direct regulatory pathway PMID:15850610
18. The changes in levels of blood coagulation factor ii in folic acid deficient rats are reversed by treatment with folic acid. PMID:16046705
19. F2R genetic variants may influence the natural history of CHD in patients at high risk of cardiovascular events. PMID:17347481
20. PAR-3 is able to signal autonomously to induce IL-8 release mediated by ERK1/2 phosphorylation, which contributes actively to inflammatory responses PMID:18264801
21. Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells. PMID:18836030
22. This study demonstrates that the anticoagulant profile of thrombin often caused by a mutation of the thrombin scaffold finds its likely molecular origin in the stabilization of the inactive E* form. PMID:19473969
23. Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. PMID:19586901

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HGNC: 3539

UNIGENE: Hs.42502

KEGG: hsa:2151

STRING: 9606.ENSP00000296641

OMIM: 601919