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Recombinant Human NKG2-C type II integral membrane protein (KLRC2)

Recombinant Human NKG2-C type II integral membrane protein (KLRC2)

Code: CSB-CF012467HU

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20μg100μg

US$4223

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Express system: in vitro E.coli expression system

Species: Homo sapiens (Human)

Tag Info: 10xHis-SUMO-tag

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Target Background

Product Details

Target Names

KLRC2

Uniprot NO.

P26717

Species

Homo sapiens (Human)

Source

in vitro E.coli expression system

Expression Region

1-231

Target Protein Sequence

MSKQRGTFSEVSLAQDPKRQQRKPKGNKSSISGTEQEIFQVELNLQNPSLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNSSPNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHKIKDSDNAELNCAVLQVNRLKSAQCGSSMIYHCKHKL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

10xHis-SUMO-tag
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

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Target Background

Function(From Uniprot)

Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation.

Gene References into Functions

a 16kb deletion encompassing the NKG2C gene is associated with lower carotid intimal media thickness values and higher humoral and T-cell responses to cytomegalovirus in renal transplant recipients PMID:28987961
the data of this study extend the characterization of adaptive NK cell subsets that differentiate in response to human Cytomegalovirus, supporting a relationship between their distribution and NKG2C copy number PMID:26994220
The new method offers the potential to use SNP arrays from genome wide association studies to study the frequency of KLRC2 deletion in other populations and its association with other diseases PMID:27312142
Assessment of NK cell repertoires in 60 NKG2C(-/-) donors revealed a broad range of NK cell populations displaying characteristic footprints of adaptive NK cells, including a terminally differentiated phenotype, functional reprogramming, and epigenetic remodeling of the interferon (IFN)-gamma promoter. PMID:27117418
HLA-E regulates NKG2C+ natural killer cell function through presentation of a restricted peptide repertoire PMID:26382247
genetic polymorphism is not associated with nasopharyngeal carcinoma in China PMID:25636564
Data suggest the proinflammatory potential of NKG2C(bright) NK cells. PMID:25667418
lack of expression of NKG2C may be associated with altered control of human cytomegalovirus infection in childhood PMID:25150297
No difference in the prevalence of NKG2C deletion was observed. PMID:24305414
NKG2C receptor deletion and a functional polymorphism in its ligand HLA-E may play a role in psoriasis susceptibility PMID:24079744
NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus. PMID:24740502
NKG2Cnull does not seem to constitute a risk factor for HPV-induced cervical lesions. PMID:23911737
NKG2C zygosity influences CD94/NKG2C receptor function and the NK-cell compartment redistribution in response to human cytomegalovirus. PMID:24030638
coexpression of killer cell Ig-like receptor (KIR) and NKG2C on expanded NK cell subsets could be related to a functional contribution of KIR in cytomegalovirus infection PMID:23918974
NKG2Chi CD57hi natural killer cells are highly responsive to human cytomegalovirus-infected macrophages only in the presence of HCMV-specific antibodies, whereas they are functionally poor effectors of natural cytotoxicity. PMID:23637420
The increased expression of NKG2C in HIV patients indicate that NKG2C is important in the defense against HIV infection and progression. PMID:22074011
A significantly elevated proportion of ex vivo peripheral blood CD4 T cells, but not CD8 T cells or natural killer (NK) cells, from multiple sclerosis patients express NKG2C, which contributes to tissue injury. PMID:23396942
HCMV-infected NKG2C(+/+) children displayed higher absolute numbers of NKG2A(+) and total NK cells than NKG2C(+/-) individuals. PMID:22965785
expression by Vdelta2+ T cells is lower in pregnant women PMID:19395088
CD94/NKG2C might be involved in triggering cytotoxic lymphocytes in patients with Toxic epidermal necrolysis and Stevens-Johnson syndrome PMID:20132973
Common occurrence of NKG2-C gene deletion in the general population. PMID:12618865
NKG2C is not essential for survival and reproduction, and is not associated with rheumatic diseases PMID:14688071
strict gene regulatory mechanisms for CD94 and NKG2 gene expression on CD4+ cells PMID:15550116
CD94/NKG2C may constitute an alternative T cell activation pathway capable of driving the expansion and triggering the effector functions of a cytotoxic T cell subset. PMID:15940674

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Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Tissue Specificity

Expressed in NK cell subsets, in particular in adaptive CD57-positive NK cells (at protein level). Expressed in terminally differentiated cytotoxic gamma-delta T cells (at protein level). Expressed in alpha-beta T cells subsets (at protein level). KLRD1-K

Database Links

HGNC: 6375

UNIGENE: Hs.591157

KEGG: hsa:3822

STRING: 9606.ENSP00000371327

OMIM: 602891

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