Recombinant Human Melatonin-related receptor (GPR50)

1. GPR50 is a TbetaRI co-receptor with potential impact on cancer development PMID:29572483
2. Pre-eclampsia (PE) plasma IgG1 anti-Epstein-Barr virus nuclear antigen 1 (EBNA-1) antibody cross-reacts with placental protein G protein-coupled receptor 50 (GPR50). PMID:27181993
3. The results provide deeper insight into the functional evolution of GPR50 in mammals at the molecular level PMID:25730005
4. There was only weak female-specific association between GPR50 variants in late-life depression. No significant associations were observed in men. PMID:25798330
5. study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 in females. PMID:21565467
6. Positive expression of melatonin receptor can be found in human hypertrophic scar and normal skin, but it is higher in scar. PMID:20737950
7. we found 2 polymorphisms in the GPR50 receptor of patients with adolescent idiopathic scoliosis, but they were not present at a highly significant frequency when compared with controls PMID:20733416
8. Antibodies were used to study the expression of GPR50 in mouse, rat and human hypothalamus.GPR50 immunoreactivity (ir) was observed in dorsomedial hypothalamic (DMH) cells and in cells of the ependymal layer of the third ventricle of the hypothalamus. PMID:20210849
9. This is the first association of rs1202874 with BD and is the second positive association at the GPR50 locus. PMID:20371266
10. Results identify neurite outgrowth inhibitor NOGO-A as an interacting partner of GPR50 and found an enrichment of both Gpr50 and neuronal Nogo-A at the synapse. PMID:19699797
11. Polymorphisms in GPR50 were compared in bipolar affective disorder (BD), major depressive disorder (MDD), schizophrenia (SCZ) and controls. GPR50(Delta502-505) or a variant is a sex-specific risk factor for susceptibility to BD and SCZ. PMID:15452587
12. Results describe sequence variants in the melatonin-related receptor gene (GPR50) that associate with circulating triglyceride and HDL levels. PMID:16436372
13. GPR50, an orphan GPCR, heterodimerizes constitutively and specifically with MT(1) and MT(2) melatonin receptors PMID:16778767
14. No evidence for an association for this gene with mood disorders in a Hungarian population. PMID:18075476

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HGNC: 4506

UNIGENE: Hs.567390

KEGG: hsa:9248

STRING: 9606.ENSP00000218316

OMIM: 300207