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Recombinant Human Integral membrane protein GPR137B (GPR137B)

Recombinant Human Integral membrane protein GPR137B (GPR137B)

Code: CSB-CF009753HU

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Size:

20μg100μg

US$5480

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Express system: in vitro E.coli expression system

Species: Homo sapiens (Human)

Tag Info: N-terminal 10xHis-tagged

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Product Details
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Target Background

Product Details

Target Names

GPR137B

Uniprot NO.

O60478

Species

Homo sapiens (Human)

Source

in vitro E.coli expression system

Expression Region

1-399

Target Protein Sequence

MRPERPRPRGSAPGPMETPPWDPARNDSLPPTLTPAVPPYVKLGLTVVYTVFYALLFVFI YVQLWLVLRYRHKRLSYQSVFLFLCLFWASLRTVLFSFYFKDFVAANSLSPFVFWLLYCF PVCLQFFTLTLMNLYFTQVIFKAKSKYSPELLKYRLPLYLASLFISLVFLLVNLTCAVLV KTGNWERKVIVSVRVAINDTLFVLCAVSLSICLYKISKMSLANIYLESKGSSVCQVTAIG VTVILLYTSRACYNLFILSFSQNKSVHSFDYDWYNVSDQADLKNQLGDAGYVLFGVVLFV WELLPTTLVVYFFRVRNPTKDLTNPGMVPSHGFSPRSYFFDNPRRYDSDDDLAWNIAPQG LQGGFAPDYYDWGQQTNSFLAQAGTLQDSTLDPDKPSLG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

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Target Background

Function(From Uniprot)

Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy.; Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polarization.

Subcellular Location

Lysosome membrane; Multi-pass membrane protein.

Protein Families

GPR137 family

Tissue Specificity

Expressed in kidney, heart, brain and placenta.

Database Links

HGNC: 11862

UNIGENE: Hs.498160

KEGG: hsa:7107

OMIM: 604658

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