Recombinant Human Galanin receptor type 1 (GALR1)

1. High methylation of GALR1 is associated with head and neck cancer. PMID:27027429
2. Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma. PMID:27685843
3. The MOR-Gal1R heteromer can explain previous results showing antagonistic galanin-opioid interactions and offers a new therapeutic target for the treatment of opioid use disorder PMID:28007761
4. GAL and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis PMID:26572146
5. Variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events. PMID:24706871
6. GALR1 methylation is associated with endometrial cancer. PMID:23727823
7. Moreover, we have identified a novel role for the GalR1/galanin receptor-ligand axis in chemoresistance, providing evidence to support its further evaluation as a potential therapeutic target and biomarker in colorectal cancer . PMID:22859720
8. Genetic variants in the GALR1 gene are associated with a protective effect in nicotine dependence. PMID:21796100
9. The results of this study suggested an association between variation at the GALR1 locus and baseline craving for tobacco in smokers seeking cessation treatment. PMID:21430647
10. it has been demonstrated that GalR1-5-HT1A receptors heteromerize. PMID:20171159
11. disregulation of galanin receptor 1 may lead to uncontrolled proliferation and neoplastic transformation PMID:15767248
12. The analyzed single nucleotide polymorphisms in GAL and GALR1 do not play major role in early onset obesity or dietary fat intake in obese children and adolescents. PMID:15930442
13. There was no effect of GALR1 on alcoholism risk. PMID:17083333
14. Data suggest that galanin stimulates cortisol secretion from human inner adrenocortical cells, acting through GAL-R1 coupled to the adenylate cyclase/PKA-dependent signaling cascade via a Ptx-sensitive Galpha protein. PMID:17982695
15. GalR1 is internalized via the clathrin-dependent, endocytic pathway and then, to a large extent, delivered to lysosomes for degradation through the lysosome-targeting signal YXXO PMID:18385373
16. GAL, coding for the neuropeptide galanin, and GALR1, a galanin receptor, were identified as candidate genes of oncogenesis in squamous cell carcinoma using a survey of parallel chromosomal alterations and gene expression studies in 10 SCC cell lines. PMID:18973137
17. GALR1 is a tumor suppressor gene in head and neck squamous cell carcinoma PMID:19047085

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HGNC: 4132

UNIGENE: Hs.272191

KEGG: hsa:2587

STRING: 9606.ENSP00000299727

OMIM: 600377