Recombinant Human G-protein coupled receptor 87 (GPR87)

1. the basal activity of GPR87 was investigated. PMID:27865873
2. we reported that GPR87 expression was significantly upregulated in pancreatic cancer, and higher GPR87 correlated with shorter overall survival of patients with pancreatic cancer. PMID:28288630
3. knockdown of GPR87 led to a p53-dependent signal transduction and caused apoptosis in the bladder cancer cells. PMID:26473854
4. This study aimed to clarify the role of GPR87 in urothelial carcinoma of the bladder. PMID:23752273
5. GPR87 promotes the growth and metastasis of CD133(+) cancer stem-like cells, and our findings may reveal new targets for HCC prevention or therapy PMID:23593389
6. Results suggest that the GPR87 is a LPA receptor which evolved from a common ancestor of P2Y receptors. PMID:17905198
7. G-protein coupled receptor(GPR87) stands out as a candidate for further target validation due to its marked overexpression and correlation on a mutation-based level to squamous cell carcinoma PMID:18057535
8. Human GPR87 mRNA transcript was preferentially overexpressed in squamous cell carcinomas. Up-regulation of both, transcript and protein, was detected in samples of SCC of the lung, cervix, skin and head and neck (pharynx, larynx and epiglottis). PMID:18183596
9. GPR87 knockdown sensitized cancer cells to DNA damage-induced growth suppression via enhanced p53 stabilization and activation. PMID:19602589

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HGNC: 4538

UNIGENE: Hs.591292

KEGG: hsa:53836

STRING: 9606.ENSP00000260843

OMIM: 606379