Recombinant Human Aquaporin-7 (AQP7)-VLPs

Code: CSB-MP001967HU

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Express system: Mammalian cell

Species: Homo sapiens (Human)

Tag Info: C-terminal 10xHis-tagged
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Product Details
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Target Background

Product Details

Target Names

AQP7

Uniprot NO.

O14520

Research Area

Signal Transduction

Species

Homo sapiens (Human)

Source

Mammalian cell

Expression Region

1-342aa

Target Protein Sequence

MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGVNLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTGMLQLCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAINPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITVLPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length

Tag Info

C-terminal 10xHis-tagged
If you have specified tag type, please tell us and we will check if it's possible to develop.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Buffer

Lyophilized from PBS, 6% Trehalose, pH 7.4.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80°C. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.

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Target Background

Function(From Uniprot)

Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH. The channel is also permeable to urea. Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney.

Gene References into Functions

ex vivo studies in human primary adipocytes, demonstrate that perilipin 1 binds to AQP7, and that catecholamine activated protein kinase A phosphorylates the N-terminus of AQP7, thereby reducing complex formation PMID:27832861
a direct involvement of AQP7 in water and glycerol transport PMID:24376702
AQP7-specific glycerol transport was furthermore found to be specifically inhibited. PMID:24334538
REVIEW: the current knowledge on the role of the glycerol channels AQP7 and AQP9 in controlling glycerol metabolism in adipose tissue and liver PMID:24463099
AQP7 overexpression may be related to insulin sensitivity and glucose homeostasis in women with the polycystic ovary syndrome. PMID:23235401
AQP7 is expressed in human and mouse oocytes and upregulated by cryoprotectants. PMID:23290745
AQP7 is regulated in response to physical training in a gender-dependent manner in adipose tissue. PMID:23001483
The discovery of an association between urine glycerol loss and a platelet secretion defect is a novel one, and our findings imply the involvement of AQPs in platelet secretion. PMID:22899094
There is a coordinated regulation of adipose AQP7 and hepatic AQP9 gene expression that is distorted in metabolic syndrome X. PMID:22425521
In all of the 33 investigated semen samples, we observed AQP7 binding to the sperm sur-face with different intensity and modality. PMID:22206455
Diazoxide may have an impact on myocardial water balance and glycerol energy supply by decreasing relative aquaporin-7 expression during coronary artery bypass grafting. PMID:21609198
these data suggest a subtle regulation between adipose depots of the sole adipose aquaporin, AQP7, which is unbalanced in obesity and T2D. PMID:20463097
determination of genomic structure, promotor analysis and functional mutation PMID:11952783
In summary, our data show that the AQP7 gene is differentially expressed in adipose tissue of lean and obese individuals. PMID:16325777
AQP7 downregulation is pathogenic for obesity and/or type 2 diabetes. PMID:17351148
Dysfunction of AQP7 in the periadventitial fat may trigger the inflammation involved in aatherosclerosis. PMID:17562358
Expression of AQP7 is down-regulated in women with severe obesity. The expression of this glycerol channel is not affected by type 2 diabetes. PMID:17566090
increased gene expression in visceral adipose tissue and liver in morbid obesity PMID:18401671
we found a greater expression found in visceral fat, and between subcutaneous adipose AQP7 and hepatic aquaporin 9 gene expression within the context of human morbid obesity PMID:19615702