Recombinant Human Alpha-1D adrenergic receptor (ADRA1D)

1. Hetero-oligomerization of a1B/D-adrenergic receptor with the chemokine (C-X-C motif) receptor 4:atypical chemokine receptor 3 heteromeric complex is required for a1B/Dadrenergic receptor function. PMID:28862946
2. processing of the ADRA1D NT domain is a physiological mechanism employed by cells to generate a functional ADRA1D isoform with optimal pharmacodynamic properties. PMID:27382054
3. expression of carboxyl terminus-truncated alpha1D-adrenoceptors alters ERK and p38 phosphorylation state. PMID:27146292
4. Immunoreactivity for ADRA2D was densely distributed in submucosal glands of nasal turbinates. PMID:26739946
5. In conclusion, our work clarified some cellular aspects promoted by alpha1D-AR activity modulation and supports a further pharmacological approach in the cure of hormone-refractory PC, by targeting specifically this AR subtype PMID:26621245
6. This study showed that ADRA1D gene involved in neuronal growth and cerebellum development and associated with neurological and psychological disorders. PMID:26381449
7. alpha1A-adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1, IGF-1, hyaluronan and PIP production in human skin fibroblasts. PMID:24844469
8. Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation. PMID:25481381
9. Mean alpha-receptor stain rates in renal pelvis were 2.65 +/- 0.74, 1.35 +/- 0.81 and 2.9 +/- 0.30 for alpha 1A, 1B and 1D, respectively. For calyces, the rates are 2.40 +/- 0.82, 1.50 +/- 0.76 and 2.75 +/- 0.44 for alpha 1A, 1B and 1D, respectively. PMID:23877383
10. alpha(1)(D)-adrenoceptors in the lower urinary tract might play an important role in the pathophysiology of lower urinary tract disorders. [review] PMID:23205498
11. Data show that alpha-dystrobrevin-1 recruits alpha-catulin, which supersensitizes alpha(1D)-AR functional responses by recruiting effector molecules to the signalosome. PMID:21115837
12. Genetic characteristics associated with response to domperidone therapy included polymorphisms in the drug transporter gene ABCB1, the potassium channel KCNH2 gene, and alpha1D--adrenoceptor ADRA1D gene. PMID:21063774
13. Data show thah activation of alpha(1)A- or alpha(1)B-adrenergic receptors inhibits serum-promoted cell proliferation, whereas alpha(1)D-AR activation does not show such an inhibitory effect. PMID:12409310
14. These studies suggest that gC1qR interacts specifically with alpha1B- and alpha1D-, but not alpha1A-ARs, and this interaction depends on the presence of an intact C-tail. PMID:14626446
15. cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors PMID:14736874
16. alpha(1A)- and alpha(1D)-adrenergic receptors mediate G(1)-S cell-cycle arrest PMID:15297446
17. Human ureter was endowed with each alpha1 AR subtype, although alpha1D and alpha1A ARs were prevalent over alpha1B ARs. PMID:15690361
18. alpha1D-adrenergic receptors are regulated by syntrophins through a PDZ domain-mediated interaction PMID:16533813
19. Differential methylation of proximal GC boxes in the ADRA1D promoter disrupts Sp1 binding in a cell-specific manner resulting in repression of basal alpha1dAR expression. PMID:17384146
20. ADRA1D polymorphisms are predictive markers of the response to beta-blockers PMID:17404580
21. Stimulation of alpha(1D)-ARs by picomolar phenylephrine concentrations devoid of any contractile vascular effects, induces a proangiogenic phenotype in endothelial cells that is enhanced in a hypoxic environment. PMID:17660397
22. In the proximal and medial ureter, the distribution of ARs was alpha 1d > or = alpha 1a > alpha 1b; In the distal ureter, the distribution of ARs was alpha 1d > alpha 1a > alpha 1b PMID:17681068
23. expression in distal ureter higher than in proximal and mid ureter but not statistically significant PMID:17973108
24. Investigate role of ADRA1D amino residues in binding of beta-adrenergic antagonists (prazosin/tamulosin). PMID:18187928
25. ADRA1A expression was decreased in end stage renal disease. Functional receptor changes mediated vascular hypersensitivity to phenylephrine. PMID:18257748
26. ADRA1D induces vascular smooth muscle apoptosis via a p53-dependent mechanism. PMID:18628404
27. Our data indicate that carboxyl terminus-truncated alpha(1D)-adrenoceptors are fully functional and subjected to regulation by phosphorylation. The roles of the carboxyl termini differ among alpha(1)-adrenoceptor subtypes. PMID:19458937

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HGNC: 280

UNIGENE: Hs.557

KEGG: hsa:146

STRING: 9606.ENSP00000368766

OMIM: 104219