Recombinant Human 5-hydroxytryptamine receptor 6 (HTR6)

1. Serotonin 6 receptor has a role in Alzheimer's disease and depression PMID:26449188
2. that HTR6 plays an important role in modulating seizure activity and that the blockade of the 5-HT6 receptor/mTOR pathway could be a potential therapeutic target for epilepsy treatment PMID:25034463
3. Studies indicate that serotonin 5-HT6 receptor (5-HT6R) has been proposed as a promising drug target for cognition enhancement in Alzheimer's disease (AD). PMID:24850589
4. [review] Controlling the activity of 5-HTR6 receptors seems to provide benefits by alleviating cognitive impairments. PMID:23844689
5. Data indicate that hydrogen-bond formation of a methoxy or hydroxy group is not important for binding at the 5-HT6 receptor. PMID:23542166
6. The human cloned 5-HT6 receptor is stably transfected in HeLa cells. PMID:15482912
7. When expressed in pyramidal neuron progenitors, serotonin receptor 5-HT6 transgene decreases the migration speed of cortical pyramidal neurons, thereby affecting a fundamental step in the assembly of neural circuits. PMID:22833193
8. These observations suggest that recruitment of mTOR by prefrontal 5-HT(6) receptors contributes to the perturbed cognition in schizophrenia, offering new vistas for its therapeutic control. PMID:23027611
9. There was a statistically significant difference in semantic memory scores among the three genotype groups of T267C in 5-HT6. PMID:21728060
10. present findings showed the presence of a higher density of 5-HT(6) receptors, as labeled by [(125)I]SB-258585, in striatum than in hippocampus and prefrontal cortex, and specifically within the neuronal body PMID:22278721
11. results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia. PMID:22745941
12. [review] Since discovery of the 5-HT6 receptor and development of its small-molecule ligands, neurochemical and localization studies have clearly demonstrated its central role in modulating GABAergic neurotransmission across brain structures and networks. PMID:21329782
13. detected association between 2 markers (rs6693503 and rs1805054) and three markers (rs6693503, rs1805054 and rs4912138) in HTR6 and METH-induced psychosis respectively. HTR6 may play important role in pathophysiology of METH-induced psychosis in Japanese PMID:20705401
14. Common variants in the gene for HT6R do not contribute to obesity. PMID:21273698
15. we found no association involving HTR6 polymorphism and mood disorder in the Japanese population PMID:20394784
16. Data show that analogues of 5-cyclic amine-3-arylsulfonylindazoles have been identified as high-affinity 5-HT(6) receptor ligands. PMID:20170099
17. Jab1 provides a novel signal transduction pathway for 5-HT(6)R and may play an important role in 5-HT(6)R-mediated behavior changes in the brain PMID:20093369
18. SNP might have a role in the etiology of suicide in male subjects in the Portuguese population. PMID:19782122
19. 5-HT6 receptor gene polymorphism C267T is associated with Parkinson's disease. PMID:11889255
20. Association of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease. apolipoprotein E epsilon 4 status. the 267C allele of the 5-HT(6) receptor gene may not be a genetic risk factor for AD. PMID:12023056
21. significant relationship between 5-HT(6) receptor gene polymorphism (C267T) and self-transcendence PMID:14698468
22. These data do not support the idea that the 5-HT(6) receptor gene plays a major role in the etiopathogenesis of schizophrenia. PMID:15048641
23. The serotonin type 6 (5-HT(6)) receptor is a G-protein coupled receptor (GPCR) coupled to a stimulatory G-protein (G(S)). PMID:15737640
24. In aging control patients, the 5-HT6 receptor was expressed by pyramidal cells and some stellate cells,in layers II-V, and layer I, where a distinct label was observed in neurons and surrounding fibers.In AD patients was significantly decreased by 40%. PMID:16640790

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HGNC: 5301

UNIGENE: Hs.22180

KEGG: hsa:3362

STRING: 9606.ENSP00000289753

OMIM: 601109