Recombinant Dog Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)

Code: CSB-CF895472DO
Size:
20μg
20μg100μg
US$3707
Quantity:
Express system: in vitro E.coli expression system
Species: Canis lupus familiaris (Dog) (Canis familiaris)
Tag Info: N-terminal 10xHis-tagged
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Product Details

Target Names
SLC2A4
Uniprot NO.
Species
Canis lupus familiaris (Dog) (Canis familiaris)
Source
in vitro E.coli expression system
Expression Region
1-162
Target Protein Sequence
TSIFETAGVGQPAYATIGAGVVNTVFTLVSVFLVERAGRRTLHLLGLAGMCGCAILMTIA LLLLERLPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFCNWTS NFIIGMGFQYIAXAMGPYVFLLFAVLLLAFFIFTFLKVPETR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
full length protein
Tag Info
N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Troubleshooting and FAQs
Datasheet & COA
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Customer Reviews and Q&A

 Customer Reviews

Target Background

Function(From Uniprot)
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.
Gene References into Functions
  1. Results indicate that the state of conditioning had a significant effect on the glucose transporter-4 protein (GLUT4) expression at the surface of mononuclear cells. PMID:25236492
  2. Damage of cardiac function during cardiopulomnary bypass are mostly associated with lower expression of Glut-4 mRNA. PMID:23111893
  3. Chronic heart failure selectively induces regional heterogeneity of insulin-responsive glucose transporters, GLUT4/12. PMID:21849635
  4. Suppressed translocation of GLUT-4 was also evident in dogs receiving 30-min ischemia PMID:18535164

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Subcellular Location
Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region.
Protein Families
Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
Database Links
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