Recombinant Danio rerio Gap junction alpha-1 protein (gja1)

1. Data show that Connexin43 (Cx43) was identified as the gene causing the short-of-fin (sof) phenotype, in which the fin ray segments are shorter but the vertebrae are normal. PMID:27129238
2. serpinh1b is molecularly and functionally downstream of cx43. The gene serpinh1b codes for a protein called Hsp47, a molecular chaperone responsible for proper folding of procollagen molecules. PMID:26103547
3. Hapln1a-ECM stabilizes the secreted growth factor Semaphorin3d (Sema3d), which has been independently shown to mediate Cx43 dependent phenotypes during regeneration. PMID:26828861
4. Hapln1a has a critical role in connexin43-dependent growth and patterning in the regenerating fin skeleton PMID:24533114
5. increased expression in Dupuytren's disease PMID:24359029
6. Sema3d functions in a common molecular pathway with Cx43 cell proliferation and joint formation PMID:22542598
7. Data show that the cultured fibroblasts from patients with ossification of the posterior longitudinal ligament (OPLL) exhibited osteogenic characteristics, in which Cx43 played an important role. PMID:21311398
8. Studies indicate that Cardiomyogenesis is determined by stimuli from the cellular microenvironment, where connexin43 may play an important role. PMID:21931658
9. Data demonstrate a cross-talk between IGF-1R and AT-1R in AT-II and IGF-1-induced Cx43 expression in SV SMCs involving Erk 1/2 and downstream activation of the AP-1 transcription factor. PMID:20731749
10. These results of this study suggested that alterations of astrocyte connexins might be involved in the suicide process and provide further evidence implicating astrocytes in psychopathology. PMID:21571253
11. Gap junctional intercellular communication in human bladder smooth muscle cells and suburothelial myofibroblastsdepend of Cx43 rather than on Cx45. PMID:21674053
12. Critical role of connexin43 in zebrafish late primitive and definitive hematopoiesis. PMID:20020200
13. Cx43 is crucial for TJ reassembly at the blood-testis barrier during its cyclic restructuring throughout the seminiferous epithelial cycle of spermatogenesis PMID:20921394
14. Neonatal murine atrial myocytes showed similar abundances of Cx40 and Cx43 proteins, while ventricular myocytes contained at least 20 times more Cx43 than Cx40. PMID:19486903
15. There was a lack of membranous distribution of connexins or a shift from moderately membranous immunoreactivity to predominantly cytoplasmic accumulation of CX32 and CX43 in studied colon tumors. PMID:20133984
16. Cx48.5, Cx44.1, Cx43 have roles in lens development PMID:14648847
17. The fin length mutant short fin (sof), which causes defects in the length of bony fin ray segments, is caused by mutations in the connexin43 (cx43) gene. PMID:15649473
18. molecular cloning; Cx43alpha1 gap junctions are likely to have conserved roles in vertebrate embryonic development PMID:15895415
19. Measurable differences in Cx43 function may be correlated with the severity of defects in bone length. PMID:17599838
20. Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration. PMID:18406403
21. Results reveal a correlation between the level of Cx43 expression in the fin ray mesenchyme and the location of joints in developing zebrafish. PMID:19150347
22. role of Cx43.4 appears to be conserved given that its ortholog, human Cx45, is able to functionally compensate for zebrafish Cx43.4 during L-R patterning PMID:19799895

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UNIGENE: Dr.75809

KEGG: dre:30236

STRING: 7955.ENSDARP00000061260