Recombinant Chicken Cadherin-2 (CDH2)

1. in chicken and mouse embryos, PAPC expression is tightly regulated by the clock and wavefront system in the posterior PSM and exhibits a striking complementary pattern to N-cadherin PMID:28087631
2. N-cadherin stops the leftward cell movements and that this termination is an essential step in the establishment of left-right asymmetry PMID:25117685
3. Inhibition of ADAM10 can inhibit Pax6 expression and N-cadherin ectodomain shedding in retinal cells, possibly affecting neurite outgrowth and ganglion cell differentiation. PMID:23129104
4. These findings suggest that ligand-selective mechanotransduction may supersede differences in cadherin binding affinities in regulating intercellular contacts. PMID:22718345
5. overexpressing N-cadherin on axons prevents the formation of the lateral funiculus and the spinocerebellar tract PMID:23115176
6. Data found that deployment of the E- to N-cadherin switch program varies considerably along the embryonic axis. PMID:22684994
7. N-Cadherin is a retinoic acid-regulated developmental gene that has been identified as participating in building the heart during embryonic development. PMID:22254040
8. Regulation of cadherin expression by gonadotropins and the presence of N-cadherin in the ovarian cortex suggest that these adhesion molecules are involved in ovarian morphogenesis in the chicken embryo. PMID:22019531
9. PTP1B promotes the association of p120 to the N-cadherin precursor, facilitating the trafficking of the complex from the endoplasmic reticulum to the Golgi complex. PMID:20181825
10. Expression of N-cadherin at the synaptic level on the somata and the proximal neurites of identified neuron populations has been traced selectively in the developing chicken visual system. PMID:15312902
11. changes in the molecular composition of the N-cadherin complex (represented by the uncoupling of p120-catenin and association with presenilin 1) may correspond to distinct functional states of the complex involved in synaptic maturation PMID:16046145
12. Co-immunoprecipitation and co-clustering paradigms were used to show that both NCAM and N-cadherin can interact with the 3Ig IIIC isoform of the FGFR1 in a number of cell types. PMID:17005551
13. PIP5KIgamma-mediated generation of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) at sites of N-cadherin contacts regulates intercellular adhesion strength, an effect due in part to PI(4,5)P2-mediated regulation of gelsolin. PMID:17538019
14. Treatment of cultures with C-type natriuretic peptide significantly increased N-cadherin, and collagen type X expression, glycosaminoglycan synthesis and chondrogenesis PMID:18461555
15. novel vimentin-linked/N-cadherin gamma-catenin junction provides the tensile strength necessary to establish and maintain structural integrity in tissues that lack desmosomes, such as the crystalline lens. PMID:18514185
16. CDH2 is associated with CTNNB1 to promote neural crest cell migration (velocity of migration is calculated). PMID:15254905

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UNIGENE: Gga.1917

KEGG: gga:414745

STRING: 9031.ENSGALP00000024371