Recombinant Chicken Basigin (BSG)

CSB-CF002831CH

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20μg100μg

US$5241

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Express system: in vitro E.coli expression system

Species: Gallus gallus (Chicken)

Tag Info: N-terminal 10xHis-tagged

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Product Details
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Target Background

Product Details

Target Names

BSG

Uniprot NO.

P17790

Species

Gallus gallus (Chicken)

Source

in vitro E.coli expression system

Expression Region

22-388

Target Protein Sequence

AGGDATAGFIKSPLSQRRLTQDSVELHCEAVGSPIPEIQWWFEGNEPNETSAQLWDGAWQDRVQINATYNLHSTSTIYIANLTSDDSGTYECRASNDPDRNHLSKSPKVKWIRSQANVLVIERPVITGQYSSSADKVVLSCNISAPPTLIKGHKWMLGDKVLKTDESDASSYISYTIEGKVEDHSGVYECIYNTNPVAKGNVSIEVEPQVVAYKKSEHGNEGDVGVLTCKSPSYPPVDHWAWYKSGQTVPLESSAGIYNISRTGNKTELRILKLNIEQDMGDYSCNGTNMKGSGSATVNLRVRSRLAALWPFLGIVAEVLVLVTIIFIYEKRRKPDEVLDDDDGGSAPLKSNATNHKDKNVRQRNAN

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 10xHis-tagged

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Description

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Target Background

Function

Essential for normal retinal maturation and development. Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors. In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors.; Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells. Plays an important role in targeting the monocarboxylate transporters SLC16A1/GLUT1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane. Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling. Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells.

Subcellular Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein.

Tissue Specificity

[Isoform 1]: Retinal cone photoreceptors (at protein level).; [Isoform 2]: Brain endothelial cells, kidney epithelial cells and erythroblasts (at protein level).

Database Links

UNIGENE: Gga.39023

KEGG: gga:770363

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