Recombinant Cat Kit ligand (KITLG)

Code: CSB-CF012376CA

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Size:

20μg100μg

US$4358

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Express system: in vitro E.coli expression system

Species: Felis catus (Cat) (Felis silvestris catus)

Tag Info: N-terminal 10xHis-tagged

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Target Background

Product Details

Target Names

KITLG

Uniprot NO.

P79169

Alternative Names

KITLG; SCF; Kit ligand; Mast cell growth factor; MGF; Stem cell factor; c-Kit ligand

Species

Felis catus (Cat) (Felis silvestris catus)

Source

in vitro E.coli expression system

Expression Region

26-274

Target Protein Sequence

KGLCRNRVTDDVKDVTKLVANLPKDYKIALKYVPGMDVLPSHCWISVMVEQLSVSLTDLLDKFSNISEGLSNYSIIDKLVKIVDDLVECVEGHSSENVKKSSKSPEPRLFTPEEFFRIFNRSIDAFKDLEMVASKTSECVVSSTLSPEKDSRVSVTKPFMLPPVAASSLRNDSSSSNRKATNPIEDSSIQWAVMALPACFSLVIGFAFGAFYWKKKQPNLTRTVENIQINEEDNEISMLQEKEREFQEV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins.

Gene References into Functions

In this study, we examined SCF expression in 23 samples of feline mast cell tumors (MCTs). SCF expression was detected in 10 cutaneous MCTs and a case of splenic mastocytosis. PMID:30213375
Results demonstrate that SCF promotes follicle development by upregulating c-kit mRNA expression and AKT phosphorylation. EGF suppresses the stimulating effect of SCF, leading to downregulation of FSHr expression. PMID:27279472

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Subcellular Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Secreted.; [Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium. Cell projection, filopodium.; [Soluble KIT ligand]: Secreted.

Protein Families

SCF family

Database Links

KEGG: fca:493937

STRING: 9685.ENSFCAP00000020444

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