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Recombinant Cat C-X-C chemokine receptor type 4 (CXCR4)

Recombinant Cat C-X-C chemokine receptor type 4 (CXCR4)

Code: CSB-CF006254CA

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Size:

20μg100μg

US$5136

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Express system: in vitro E.coli expression system

Species: Felis catus (Cat) (Felis silvestris catus)

Tag Info: N-terminal 10xHis-tagged

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Product Details
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Target Background

Product Details

Target Names

CXCR4

Uniprot NO.

P56498

Species

Felis catus (Cat) (Felis silvestris catus)

Source

in vitro E.coli expression system

Expression Region

1-353

Target Protein Sequence

MDGFRIYPSDNYTEDDLGSGDYDSMKEPCFREENAHFNRIFLPTVYSIIFLTGIVGNGLV ILVMGYQKKLRSMTDKYRLHLSVADLLFVLTLPFWAVDAVANWYFGKFLCKAVHVIYTVN LYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVRE ADGRYICDRFYPSDSWLVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGYQKRKALK TTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFESTVHKWISITEALAFFHCCLNP ILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

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Target Background

Function(From Uniprot)

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.

Gene References into Functions

CD4+ CD25- cells were less susceptible to FIV binding and entry which correlated with increased surface expression of FIV coreceptor CXCR4. PMID:15795282
These findings provide direct evidence for a sequential interaction of FIV Env with CD134 and CXCR4 . PMID:16501119
Expression of CD134 and CXCR4 on feline T and B and dendritic cells (and macrophages was examined and the kinetics of feline immunodeficiency virus replication were assessed. PMID:18089752

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome.

Protein Families

G-protein coupled receptor 1 family

Database Links

KEGG: fca:493676

STRING: 9685.ENSFCAP00000014443

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