SELE; E-selectin; CD62 antigen-like family member E; Endothelial leukocyte adhesion molecule 1; ELAM-1; Leukocyte-endothelial cell adhesion molecule 2; LECAM2; CD antigen CD62E
Species
Bos taurus (Bovine)
Source
in vitro E.coli expression system
Expression Region
23-485
Target Protein Sequence
WSYHASTEMMTFEEARDYCQKTYTALVAIQNQEEIEYLNSTFSYSPSYYWIGIRKINGTWTWIGTNKSLTKEATNWAPGEPNNKQSDEDCVEIYIKREKDSGKWNDEKCTKQKLALCYKAACNPTPCGSHGECVETINNYTCQCHPGFKGLKCEQVVTCPAQKHPEHGHLVCNPLGKFTYNSSCSISCAEGYLPSSTEATRCMSSGEWSTPLPKCNVVKCDALSNLDNGVVNCSPNHGSLPWNTTCTFECQEGYKLTGPQHLQCTSSGIWDNKQPTCKAVSCAAISHPQNGTVNCSHSVVGDFAFKSSCHFTCAEGFTLQGPTQVECTAQGQWTQRVPVCEVVRCSRLDVSGKLNMNCSGEPVLGTECTFACPERWTLNGSVVLTCGATGHWSGMLPTCEAPTVSQTPLAVGLSTAGVSLVTIPSFLFWLLKRLQKKAKKFSPASSCSSLKSNGCYSTPSKLI
Note: The complete
sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is
translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application,
please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Storage Condition
Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.
Gene References into Functions
The e-selectin/biliverdin reductase pathway participates in the inhibitory process of hypoxia in pulmonary artery endothelial cell apoptosis which is mediated by the mitochondrial-dependent apoptosis pathway.PMID:27033411
Five single nucleotide polymorphisms (SNPs) from different exons in selectin SELP, two in selectin SELL and one in selectin SELE were taken forward to genotyping in 337 Holstein Friesian heifers using PCR-RFLP.PMID:28419109
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Subcellular Location
Cell membrane; Single-pass type I membrane protein.