NTRK1/NTRK3/NTRK2 Recombinant Monoclonal Antibody

Code: CSB-RA236968A0HU

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Size:

50μl100μl

US$210

Quantity:

Species Reactivity: Human

Application: ELISA, IHC

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Target Background

Product Details

Uniprot NO.

P04629 Q16288 Q16620

Target Names

NTRK1/NTRK3/NTRK2

Alternative Names

gp140trk antibody; High affinity nerve growth factor receptor antibody; High affinity nerve growth factor receptor precursor antibody; MTC antibody; Neurotrophic tyrosine kinase receptor type 1 antibody; NTRK1 antibody; NTRK1_HUMAN antibody; Oncogene TRK antibody; p14-TrkA antibody; p140 TrkA antibody; p140-TrkA antibody; Slow nerve growth antibody; Trk A antibody; TRK antibody; Trk-A antibody; TRK1 antibody; TRK1-transforming tyrosine kinase protein antibody; Tropomyosin-related kinase A antibody; Tyrosine kinase receptor A antibody; Tyrosine kinase receptor antibody; EC 2.7.10.1 antibody; ETS related protein neurotrophic receptor tyrosine kinase fusion antibody; ETS related protein neurotrophic receptor tyrosine kinase fusion protein antibody; ETV6 NTRK3 fusion antibody; GP145 TrkC antibody; gp145(trkC) antibody; GP145-TrkC antibody; GP145TrkC antibody; Neurotrophic tyrosine kinase receptor type 3 antibody; Neurotrophin 3 receptor antibody; NT 3 growth factor receptor antibody; NT 3 growth factor receptor precursor antibody; NT 3 receptor antibody; NT-3 growth factor receptor antibody; Ntrk3 antibody; NTRK3_HUMAN antibody; OTTHUMP00000192915 antibody; TRK C antibody; Trk-C antibody; TRKC antibody; TrkC tyrosine kinase antibody; Tyrosine kinase receptor C antibody; AI848316 antibody; BDNF tropomyosine receptor kinase B antibody; BDNF/NT 3 growth factors receptor antibody; BDNF/NT-3 growth factors receptor antibody; Brain derived neurotrophic factor receptor antibody; C030027L06Rik antibody; EC 2.7.10.1 antibody; GP145 TrkB antibody; GP145-TrkB antibody; GP145-TrkB/GP95-TrkB antibody; GP95 TrkB antibody; Neurotrophic receptor tyrosine kinase 2 antibody; Neurotrophic tyrosine kinase receptor type 2 antibody; Neurotrophin receptor tyrosine kinase type 2 antibody; NTRK 2 antibody; Ntrk2 antibody; NTRK2_HUMAN antibody; Obesity, hyperphagia, and developmental delay, included antibody; RATTRKB1 antibody; Tkrb antibody; Trk B antibody; Trk-B antibody; TRKB antibody; TrkB tyrosine kinase antibody; TRKB1 antibody; Tropomyosin related kinase B antibody; tyrosine kinase receptor B antibody; Tyrosine receptor kinase B antibody

Species Reactivity

Human

Immunogen

A synthesized peptide from human NTRK1/NTRK3/NTRK2 protein

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

Rabbit IgG

Clone No.

10E6

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Scope Application

ELISA Protocol Immunohistochemistry (IHC) Protocol

Recommended Dilution

Application	Recommended Dilution
IHC	1:50-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

IHC image of CSB-RA236968A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

Description

The NTRK family of receptor tyrosine kinases—comprising TrkA (NTRK1), TrkB (NTRK2), and TrkC (NTRK3)—serves as the primary signaling hub for neurotrophins, orchestrating neuronal survival, differentiation, and synaptic plasticity throughout the nervous system. These receptors have gained substantial research attention due to their involvement in neurodegenerative diseases and their emerging role as oncogenic drivers when chromosomal rearrangements generate NTRK fusion proteins, making them compelling therapeutic targets in precision oncology.

This recombinant monoclonal antibody, clone 10E6, offers researchers a reliable tool for investigating all three Trk family members simultaneously. Developed using recombinant technology in a rabbit host system, this antibody provides the sequence-defined consistency essential for longitudinal studies and reproducible results across experiments. The monoclonal nature ensures that each vial delivers identical binding characteristics, eliminating the lot-to-lot variability that can compromise experimental interpretation when tracking subtle changes in receptor expression.

Validation in immunohistochemistry demonstrates effective performance in paraffin-embedded human brain tissue, where the antibody successfully detected Trk proteins at a 1:100 dilution using standard citrate buffer antigen retrieval. This tissue-based validation confirms utility for researchers examining neurotrophin receptor distribution in neural specimens, with recommended working dilutions ranging from 1:50 to 1:200 to accommodate varying tissue preparations and detection systems.

The unconjugated format and affinity-purified preparation provide flexibility for integration into established immunohistochemistry workflows and ELISA-based quantification studies. Whether investigating neurotrophin signaling in neuroscience research or screening for NTRK expression in tumor specimens, this antibody supports critical investigations into receptor tyrosine kinase biology and its therapeutic implications.