ITGA2B Recombinant Monoclonal Antibody

Code: CSB-RA67589MA1HU

Rate （N/A）
Review （0）

Size:

50μl100μl

US$210

Quantity:

Species Reactivity: Human

Application: ELISA, IHC

Send an Inquiry

Start an on-line Chat

Online ordering is currently available for U.S. customers only. For orders outside the U.S., please kindly submit an inquiry or start a chat with us.

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Uniprot NO.

P08514,P05106

Target Names

ITGA2B

Alternative Names

antigen CD41 antibody; BDPLT16 antibody; BDPLT2 antibody; CD41 antibody; CD41B antibody; form 2 antibody; GP2B antibody; GPalpha IIb antibody; GPIIb antibody; GT antibody; GTA antibody; HPA3 antibody; Integrin alpha 2b antibody; Integrin alpha IIb antibody; Integrin alpha-IIb light chain antibody; Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) antibody; ITA2B_HUMAN antibody; Itga2b antibody; ITGAB antibody; platelet fibrinogen receptor, alpha subunit antibody; platelet glycoprotein IIb of IIb/IIIa complex antibody; Platelet membrane glycoprotein IIb antibody; platelet specific antigen BAK antibody; PPP1R93 antibody; BDPLT16 antibody; BDPLT2 antibody; CD 61 antibody; CD61 antibody; CD61 antigen antibody; GP3A antibody; GPIIIa antibody; GT antibody; HPA 1 antibody; HPA 4 antibody; Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody; Integrin beta chain beta 3 antibody; Integrin beta-3 antibody; ITB3_HUMAN antibody; ITG B3 antibody; ITGB 3 antibody; ITGB3 antibody; NAIT antibody; platelet fibrinogen receptor antibody; Platelet fibrinogen receptor beta subunit antibody; Platelet fibrinogen receptor, beta subunit antibody; Platelet glycoprotein IIIa antibody; Platelet glycoprotein IIIa precursor antibody; Platelet membrane glycoprotein IIIa antibody; PTP antibody

Species Reactivity

Human

Immunogen

Recombinant Human ITGA2B protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

hIgG1

Clone No.

22B12

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:50-1:200

Protocols

ELISA Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

IHC image of CSB-RA67589MA1HU diluted at 1:50 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Anti-Human lgG, Fcy Fragment Specific labeled by HRP and visualized using 0.05% DAB.

Description

Integrin alpha-IIb (ITGA2B), also known as CD41 or platelet glycoprotein IIb, forms a critical heterodimeric complex with integrin beta-3 (GPIIIa/CD61) that serves as the primary fibrinogen receptor on platelet surfaces. This GPIIb/IIIa complex plays an essential role in platelet aggregation and thrombus formation, making it a key target for researchers investigating hemostasis, thrombotic disorders, and cardiovascular disease. Mutations in ITGA2B are associated with Glanzmann thrombasthenia, a rare bleeding disorder, while the receptor itself represents an important therapeutic target in antiplatelet therapy development.

This recombinant monoclonal antibody, clone 22B12, offers significant advantages for researchers requiring consistent, reproducible results across extended studies. Generated against recombinant human ITGA2B protein and expressed with a human IgG1 backbone, this antibody provides the sequence-defined specificity and lot-to-lot consistency that recombinant technology delivers. Affinity chromatography purification ensures high purity preparations suitable for demanding experimental workflows.

Validated for immunohistochemistry applications, this antibody has been successfully tested in paraffin-embedded human liver cancer tissue using the Leica Bond system at dilutions of 1:50 to 1:200. The validation protocol employed citrate buffer antigen retrieval and demonstrated clear target detection with HRP-conjugated secondary antibody visualization. The antibody is also suitable for ELISA-based detection methods, providing flexibility across different experimental platforms.

This ITGA2B antibody serves researchers studying platelet biology, megakaryocyte differentiation, tumor microenvironment interactions, and cardiovascular pathophysiology. Its human reactivity and validated performance in tissue sections make it particularly valuable for translational research connecting basic platelet biology to clinical applications.